5HLW

Crystal structure of c-Met mutant Y1230H in complex with compound 14

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ESRF BEAMLINE ID23-1
Synchrotron site	ESRF
Beamline	ID23-1
Temperature [K]	100
Detector technology	CCD
Collection date	2009-08-04
Detector	ADSC QUANTUM 315
Wavelength(s)	0.9765
Spacegroup name	P 21 21 21
Unit cell lengths	43.320, 46.690, 156.960
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	34.840 - 1.970
RMSD bond length	0.010
RMSD bond angle	1.010
Data reduction software	MOSFLM
Data scaling software	SCALA
Phasing software	PHASER
Refinement software	BUSTER (2.11.5)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	34.840	2.020
High resolution limit [Å]	1.970	1.970
Rmerge		0.235
Number of reflections	21753
<I/σ(I)>	8.8	3.4
Completeness [%]	100.0	100
Redundancy	4	3

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, HANGING DROP	8	293	Tris 100mM-MPD20%-pH8