5HLW
Crystal structure of c-Met mutant Y1230H in complex with compound 14
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 299 | 33876.3 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (Human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | B (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | C (A) | 1-[2-(1-ethylpiperidin-4-yl)ethyl]-3-(6-{[6-(thiophen-2-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)urea | non-polymer | 564.7 | 1 | Chemie (62E) | |||
| 4 | D (A) | water | water | 18.0 | 192 | Chemie (HOH) |
Sequence modifications
A: 1057 - 1355 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| His 1230 | Tyr 1230 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33876.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 600.2 | |
| All* | Total formula weight | 34476.5 |
