1FO2

CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH 1-DEOXYMANNOJIRIMYCIN

Summary for 1FO2

• Entry DOI: 10.2210/pdb1fo2/pdb
• Related: 1FMI 1FO3
• Descriptor: ALPHA1,2-MANNOSIDASE, CALCIUM ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: alpha-alpha7 barrel, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein: Q9UKM7
• Total number of polymer chains: 1
• Total formula weight: 53273.35

Authors

Vallee, F.,Karaveg, K.,Moremen, K.W.,Herscovics, A.,Howell, P.L. (deposition date: 2000-08-24, release date: 2001-01-17, Last modification date: 2011-07-13)

• Primary citation: Vallee, F.,Karaveg, K.,Herscovics, A.,Moremen, K.W.,Howell, P.L.; Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases.; J.Biol.Chem., 275:41287-41298, 2000; PubMed: 10995765; DOI: 10.1074/jbc.M006927200

Experimental method

X-RAY DIFFRACTION (2.38 Å)