5HOR

Crystal structure of c-Met-M1250T in complex with SAR125844.

Summary for 5HOR

Entry DOI	10.2210/pdb5hor/pdb
Descriptor	Hepatocyte growth factor receptor, 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea (3 entities in total)
Functional Keywords	transferase, inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35827.44
Authors	Vallee, F.,Houtmann, J.,Marquette, J.-P. (deposition date: 2016-01-19, release date: 2016-11-23, Last modification date: 2019-10-16)
Primary citation	Ugolini, A.,Kenigsberg, M.,Rak, A.,Vallee, F.,Houtmann, J.,Lowinski, M.,Capdevila, C.,Khider, J.,Albert, E.,Martinet, N.,Nemecek, C.,Grapinet, S.,Bacque, E.,Roesner, M.,Delaisi, C.,Calvet, L.,Bonche, F.,Semiond, D.,Egile, C.,Goulaouic, H.,Schio, L. Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). J.Med.Chem., 59:7066-7074, 2016 Cited by PubMed: 27355974 DOI: 10.1021/acs.jmedchem.6b00280 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation