7DCZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dcz by Molmil](/molmil-images/mine/7dcz) | Crystal Structure of BACE1 in complex with N-{3-[(4S)-2-amino-4-methyl-4H-1,3-thiazin-4-yl]-4- fluorophenyl}-5-cyanopyridine-2-carboxamide | 分子名称: | Beta-secretase 1, GLYCEROL, IODIDE ION, ... | 著者 | Koriyama, Y, Hori, A, Ito, H, Yonezawa, S, Baba, Y, Tanimoto, N, Ueno, T, Yamamoto, S, Yamamoto, T, Asada, N, Morimoto, K, Einaru, S, Sakai, K, Kanazu, T, Matsuda, A, Yamaguchi, Y, Oguma, T, Timmers, M, Tritsmans, L, Kusakabe, K.I, Kato, A, Sakaguchi, G. | 登録日 | 2020-10-27 | 公開日 | 2021-03-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based beta-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial. J.Med.Chem., 64, 2021
|
|
2K16
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2k16 by Molmil](/molmil-images/mine/2k16) | Solution structure of the free TAF3 PHD domain | 分子名称: | Transcription initiation factor TFIID subunit 3, ZINC ION | 著者 | van Ingen, H, van Schaik, F.M.A, Wienk, H, Timmers, M, Boelens, R. | 登録日 | 2008-02-22 | 公開日 | 2008-07-15 | 最終更新日 | 2024-05-08 | 実験手法 | SOLUTION NMR | 主引用文献 | Recognition of the H3K4me3 mark by the TAF3-PHD finger To be Published
|
|
2K17
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2k17 by Molmil](/molmil-images/mine/2k17) | Solution structure of the TAF3 PHD domain in complex with a H3K4me3 peptide | 分子名称: | H3K4me3 peptide, Transcription initiation factor TFIID subunit 3, ZINC ION | 著者 | van Ingen, H, van Schaik, F.M.A, Wienk, H, Timmers, M, Boelens, R. | 登録日 | 2008-02-22 | 公開日 | 2008-07-15 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Recognition of the H3K4me3 mark by the TAF3-PHD finger To be Published
|
|
8BTW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8btw by Molmil](/molmil-images/mine/8btw) | Structure of D179N BlaC from Mycobacterium tuberculosis in complex with vaborbactam | 分子名称: | Beta-lactamase, GLYCEROL, PHOSPHATE ION, ... | 著者 | Chikunova, A, Bruenle, S, Ubbink, M. | 登録日 | 2022-12-02 | 公開日 | 2023-07-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Asp179 in the class A beta-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis. Febs J., 290, 2023
|
|
8BTV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8btv by Molmil](/molmil-images/mine/8btv) | Structure of D179N BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct of sulbactam | 分子名称: | Beta-lactamase, GLYCEROL, PHOSPHATE ION, ... | 著者 | Chikunova, A, Bruenle, S, Ubbink, M. | 登録日 | 2022-12-02 | 公開日 | 2023-07-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Asp179 in the class A beta-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis. Febs J., 290, 2023
|
|
8BTU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8btu by Molmil](/molmil-images/mine/8btu) | |
8BV4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bv4 by Molmil](/molmil-images/mine/8bv4) | Structure of BlaC from Mycobacterium tuberculosis in complex with vaborbactam | 分子名称: | Beta-lactamase, GLYCEROL, PHOSPHATE ION, ... | 著者 | Chikunova, A, Bruenle, S, Ubbink, M. | 登録日 | 2022-12-01 | 公開日 | 2023-07-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Asp179 in the class A beta-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis. Febs J., 290, 2023
|
|
8OE5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8oe5 by Molmil](/molmil-images/mine/8oe5) | |
8OE1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8oe1 by Molmil](/molmil-images/mine/8oe1) | |
5NJ2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nj2 by Molmil](/molmil-images/mine/5nj2) | Crystal structure of BlaC from Mycobacterium tuberculosis bound to phosphate | 分子名称: | 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15-PENTAOXAHEPTADECAN-1-OL, ACETATE ION, ... | 著者 | Tassoni, R, Pannu, N.S, Ubbink, M. | 登録日 | 2017-03-27 | 公開日 | 2017-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | Phosphate Promotes the Recovery of Mycobacterium tuberculosis beta-Lactamase from Clavulanic Acid Inhibition. Biochemistry, 56, 2017
|
|
7A74
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7a74 by Molmil](/molmil-images/mine/7a74) | Structure of G132N BlaC from Mycobacterium tuberculosis | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase, GLYCEROL, ... | 著者 | Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M. | 登録日 | 2020-08-27 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Two beta-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics. Antimicrob.Agents Chemother., 65, 2021
|
|
5OYO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5oyo by Molmil](/molmil-images/mine/5oyo) | |
8QXY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qxy by Molmil](/molmil-images/mine/8qxy) | Xylanase from Bacillus circulans mutant E78Q bound to xylotriose | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endo-1,4-beta-xylanase, GLYCEROL, ... | 著者 | Chikunova, A, Saberi, M, Ubbink, M. | 登録日 | 2023-10-25 | 公開日 | 2024-08-21 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Bimodal substrate binding in the active site of the glycosidase BcX. Febs J., 2024
|
|
8QY2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qy2 by Molmil](/molmil-images/mine/8qy2) | Xylanase from Bacillus circulans mutant E78Q/F125A | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endo-1,4-beta-xylanase, GLYCEROL, ... | 著者 | Chikunova, A, Saberi, M, Ubbink, M. | 登録日 | 2023-10-25 | 公開日 | 2024-08-21 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Bimodal substrate binding in the active site of the glycosidase BcX. Febs J., 2024
|
|
8R86
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8r86 by Molmil](/molmil-images/mine/8r86) | |
8QXZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qxz by Molmil](/molmil-images/mine/8qxz) | Xylanase from Bacillus circulans mutant E78Q/Y69A | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Endo-1,4-beta-xylanase, ... | 著者 | Chikunova, A, Saberi, M, Ubbink, M. | 登録日 | 2023-10-25 | 公開日 | 2024-08-21 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Bimodal substrate binding in the active site of the glycosidase BcX. Febs J., 2024
|
|
8QY1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qy1 by Molmil](/molmil-images/mine/8qy1) | Xylanase from Bacillus circulans mutant E78Q/Y69A bound to xylohexaose | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, Endo-1,4-beta-xylanase, ... | 著者 | Chikunova, A, Saberi, M, Ubbink, M. | 登録日 | 2023-10-25 | 公開日 | 2024-08-21 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Bimodal substrate binding in the active site of the glycosidase BcX. Febs J., 2024
|
|
8QY0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qy0 by Molmil](/molmil-images/mine/8qy0) | Xylanase from Bacillus circulans mutant E78Q/Y69A bound to xylotriose | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endo-1,4-beta-xylanase, ZINC ION, ... | 著者 | Chikunova, A, Saberi, M, Ubbink, M. | 登録日 | 2023-10-25 | 公開日 | 2024-08-21 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Bimodal substrate binding in the active site of the glycosidase BcX. Febs J., 2024
|
|
8QY3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qy3 by Molmil](/molmil-images/mine/8qy3) | Xylanase from Bacillus circulans mutant E78Q/F125A bound to xylotriose | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, Endo-1,4-beta-xylanase, ... | 著者 | Chikunova, A, Saberi, M, Ubbink, M. | 登録日 | 2023-10-25 | 公開日 | 2024-08-21 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Bimodal substrate binding in the active site of the glycosidase BcX. Febs J., 2024
|
|
8R85
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8r85 by Molmil](/molmil-images/mine/8r85) | |