7DCZ
 
 | | Crystal Structure of BACE1 in complex with N-{3-[(4S)-2-amino-4-methyl-4H-1,3-thiazin-4-yl]-4- fluorophenyl}-5-cyanopyridine-2-carboxamide | | 分子名称: | Beta-secretase 1, GLYCEROL, IODIDE ION, ... | | 著者 | Koriyama, Y, Hori, A, Ito, H, Yonezawa, S, Baba, Y, Tanimoto, N, Ueno, T, Yamamoto, S, Yamamoto, T, Asada, N, Morimoto, K, Einaru, S, Sakai, K, Kanazu, T, Matsuda, A, Yamaguchi, Y, Oguma, T, Timmers, M, Tritsmans, L, Kusakabe, K.I, Kato, A, Sakaguchi, G. | | 登録日 | 2020-10-27 | | 公開日 | 2021-03-10 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based beta-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial.
J.Med.Chem., 64, 2021
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2K16
 | | Solution structure of the free TAF3 PHD domain | | 分子名称: | Transcription initiation factor TFIID subunit 3, ZINC ION | | 著者 | van Ingen, H, van Schaik, F.M.A, Wienk, H, Timmers, M, Boelens, R. | | 登録日 | 2008-02-22 | | 公開日 | 2008-07-15 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Recognition of the H3K4me3 mark by the TAF3-PHD finger
To be Published
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2K17
 | | Solution structure of the TAF3 PHD domain in complex with a H3K4me3 peptide | | 分子名称: | H3K4me3 peptide, Transcription initiation factor TFIID subunit 3, ZINC ION | | 著者 | van Ingen, H, van Schaik, F.M.A, Wienk, H, Timmers, M, Boelens, R. | | 登録日 | 2008-02-22 | | 公開日 | 2008-07-15 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Recognition of the H3K4me3 mark by the TAF3-PHD finger
To be Published
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8BTW
 | | Structure of D179N BlaC from Mycobacterium tuberculosis in complex with vaborbactam | | 分子名称: | Beta-lactamase, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Chikunova, A, Bruenle, S, Ubbink, M. | | 登録日 | 2022-12-02 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Asp179 in the class A beta-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis.
Febs J., 290, 2023
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8BTV
 | | Structure of D179N BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct of sulbactam | | 分子名称: | Beta-lactamase, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Chikunova, A, Bruenle, S, Ubbink, M. | | 登録日 | 2022-12-02 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Asp179 in the class A beta-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis.
Febs J., 290, 2023
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8BTU
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8BV4
 | | Structure of BlaC from Mycobacterium tuberculosis in complex with vaborbactam | | 分子名称: | Beta-lactamase, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Chikunova, A, Bruenle, S, Ubbink, M. | | 登録日 | 2022-12-01 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Asp179 in the class A beta-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis.
Febs J., 290, 2023
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8OE5
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8OE1
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5NJ2
 | | Crystal structure of BlaC from Mycobacterium tuberculosis bound to phosphate | | 分子名称: | 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15-PENTAOXAHEPTADECAN-1-OL, ACETATE ION, ... | | 著者 | Tassoni, R, Pannu, N.S, Ubbink, M. | | 登録日 | 2017-03-27 | | 公開日 | 2017-11-15 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | | 主引用文献 | Phosphate Promotes the Recovery of Mycobacterium tuberculosis beta-Lactamase from Clavulanic Acid Inhibition.
Biochemistry, 56, 2017
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7A74
 | | Structure of G132N BlaC from Mycobacterium tuberculosis | | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase, GLYCEROL, ... | | 著者 | Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M. | | 登録日 | 2020-08-27 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Two beta-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics.
Antimicrob.Agents Chemother., 65, 2021
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5OYO
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8QXY
 | | Xylanase from Bacillus circulans mutant E78Q bound to xylotriose | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endo-1,4-beta-xylanase, GLYCEROL, ... | | 著者 | Chikunova, A, Saberi, M, Ubbink, M. | | 登録日 | 2023-10-25 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | Bimodal substrate binding in the active site of the glycosidase BcX.
Febs J., 2024
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8QY2
 | | Xylanase from Bacillus circulans mutant E78Q/F125A | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endo-1,4-beta-xylanase, GLYCEROL, ... | | 著者 | Chikunova, A, Saberi, M, Ubbink, M. | | 登録日 | 2023-10-25 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Bimodal substrate binding in the active site of the glycosidase BcX.
Febs J., 2024
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8R86
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8QXZ
 | | Xylanase from Bacillus circulans mutant E78Q/Y69A | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Endo-1,4-beta-xylanase, ... | | 著者 | Chikunova, A, Saberi, M, Ubbink, M. | | 登録日 | 2023-10-25 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Bimodal substrate binding in the active site of the glycosidase BcX.
Febs J., 2024
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8QY1
 | | Xylanase from Bacillus circulans mutant E78Q/Y69A bound to xylohexaose | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, Endo-1,4-beta-xylanase, ... | | 著者 | Chikunova, A, Saberi, M, Ubbink, M. | | 登録日 | 2023-10-25 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Bimodal substrate binding in the active site of the glycosidase BcX.
Febs J., 2024
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8QY0
 | | Xylanase from Bacillus circulans mutant E78Q/Y69A bound to xylotriose | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endo-1,4-beta-xylanase, ZINC ION, ... | | 著者 | Chikunova, A, Saberi, M, Ubbink, M. | | 登録日 | 2023-10-25 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Bimodal substrate binding in the active site of the glycosidase BcX.
Febs J., 2024
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8QY3
 | | Xylanase from Bacillus circulans mutant E78Q/F125A bound to xylotriose | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, Endo-1,4-beta-xylanase, ... | | 著者 | Chikunova, A, Saberi, M, Ubbink, M. | | 登録日 | 2023-10-25 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | | 主引用文献 | Bimodal substrate binding in the active site of the glycosidase BcX.
Febs J., 2024
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8R85
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