8BTV

Structure of D179N BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct of sulbactam

Summary for 8BTV

Entry DOI	10.2210/pdb8btv/pdb
Descriptor	Beta-lactamase, TRANS-ENAMINE INTERMEDIATE OF SULBACTAM, GLYCEROL, ... (5 entities in total)
Functional Keywords	hydrolase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	1
Total formula weight	28938.18
Authors	Chikunova, A.,Bruenle, S.,Ubbink, M. (deposition date: 2022-12-02, release date: 2023-07-05, Last modification date: 2023-11-22)
Primary citation	van Alen, I.,Chikunova, A.,van Zanten, D.B.,de Block, A.A.,Timmer, M.,Brunle, S.,Ubbink, M. Asp179 in the class A beta-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis. Febs J., 290:4933-4949, 2023 Cited by PubMed: 37335937 DOI: 10.1111/febs.16892 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation