5B3J
 
 | | Activation of NMDA receptors and the mechanism of inhibition by ifenprodil | | 分子名称: | Fab, heavy chain, light chain, ... | | 著者 | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | | 登録日 | 2016-03-01 | | 公開日 | 2016-05-11 | | 最終更新日 | 2022-03-23 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Activation of NMDA receptors and the mechanism of inhibition by ifenprodil
Nature, 534, 2016
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7TE9
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7TES
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7TE4
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7TEB
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7TER
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7TEE
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7TET
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7TEQ
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5FXJ
 | | GluN1b-GluN2B NMDA receptor structure-Class X | | 分子名称: | GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1, NMDA 2B | | 著者 | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa H, H. | | 登録日 | 2016-03-02 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (6.25 Å) | | 主引用文献 | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil.
Nature, 534, 2016
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5FXK
 | | GluN1b-GluN2B NMDA receptor structure-Class Y | | 分子名称: | N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B | | 著者 | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | | 登録日 | 2016-03-02 | | 公開日 | 2016-05-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | | 主引用文献 | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil.
Nature, 534, 2016
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5FXH
 | | GluN1b-GluN2B NMDA receptor in non-active-1 conformation | | 分子名称: | N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B | | 著者 | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | | 登録日 | 2016-03-02 | | 公開日 | 2016-05-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (5 Å) | | 主引用文献 | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil.
Nature, 534, 2016
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5FXG
 | | GLUN1B-GLUN2B NMDA RECEPTOR IN ACTIVE CONFORMATION | | 分子名称: | N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B | | 著者 | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | | 登録日 | 2016-03-02 | | 公開日 | 2016-05-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (6.8 Å) | | 主引用文献 | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil.
Nature, 534, 2016
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5FXI
 | | GluN1b-GluN2B NMDA receptor structure in non-active-2 conformation | | 分子名称: | N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B | | 著者 | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | | 登録日 | 2016-03-02 | | 公開日 | 2016-05-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | | 主引用文献 | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil.
Nature, 534, 2016
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3AEH
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7TE6
 | | Crystal structure of GluN1b-2B ATD complexed to Fab5 anti-GluN2B antibody | | 分子名称: | Fab5 heavy chain, Fab5 light chain, Glutamate receptor ionotropic, ... | | 著者 | Regan, M, Tajima, N, Furukawa, H. | | 登録日 | 2022-01-04 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (4.55 Å) | | 主引用文献 | Development and characterization of functional antibodies targeting NMDA receptors.
Nat Commun, 13, 2022
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8F0O
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6USU
 | | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with L689,560 and glutamate | | 分子名称: | (2R,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid, GLUTAMIC ACID, Glutamate receptor ionotropic, ... | | 著者 | Romero-Hernandez, A, Tajima, N, Chou, T, Furukawa, H. | | 登録日 | 2019-10-28 | | 公開日 | 2020-07-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | | 主引用文献 | Structural Basis of Functional Transitions in Mammalian NMDA Receptors.
Cell, 182, 2020
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6USV
 | | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and SDZ 220-040 | | 分子名称: | (2S)-2-amino-3-[2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)biphenyl-3-yl]propanoic acid, GLYCEROL, GLYCINE, ... | | 著者 | Romero-Hernandez, A, Tajima, N, Chou, T, Furukawa, h. | | 登録日 | 2019-10-28 | | 公開日 | 2020-07-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.304 Å) | | 主引用文献 | Structural Basis of Functional Transitions in Mammalian NMDA Receptors.
Cell, 182, 2020
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8GC3
 | | Domote-bound GluK2 kainate receptors in partially-open conformation 2 | | 分子名称: | (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Bogdanovic, N, Tajima, N. | | 登録日 | 2023-03-01 | | 公開日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis for kainate receptor activation by a partial agonist
To Be Published
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8GC5
 | | Domoate-bound GluK2 kainate receptors in non-active conformation | | 分子名称: | (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Bogdanovic, N, Tajima, N. | | 登録日 | 2023-03-01 | | 公開日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | | 主引用文献 | Structural basis for kainate receptor activation by a partial agonist
To Be Published
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8GC2
 | | Domoate-bound GluK2 kainate receptor in partially-open conformation 1 | | 分子名称: | (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Bogdanovic, N, Tajima, N. | | 登録日 | 2023-03-01 | | 公開日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural basis for kainate receptor activation by a partial agonist
To Be Published
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8GC4
 | | Domoate-bound GluK2 kainate receptor in partially-open conformation 3 | | 分子名称: | (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Bogdanovic, N, Tajima, N. | | 登録日 | 2023-03-01 | | 公開日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | | 主引用文献 | Structural basis for kainate receptor activation by a partial agonist
To Be Published
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4JWX
 | | GluN2A ligand-binding core in complex with propyl-NHP5G | | 分子名称: | (2R)-amino(1-hydroxy-4-propyl-1H-pyrazol-5-yl)ethanoic acid, GluN2A | | 著者 | Hansen, K.B, Tajima, N, Risgaard, R, Perszyk, R.E, Jorgensen, L, Vance, K.M, Ogden, K.K, Clausen, R.P, Furukawa, H, Traynelis, S.F. | | 登録日 | 2013-03-27 | | 公開日 | 2013-05-29 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors.
Mol.Pharmacol., 84, 2013
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4JWY
 | | GluN2D ligand-binding core in complex with propyl-NHP5G | | 分子名称: | (2R)-amino(1-hydroxy-4-propyl-1H-pyrazol-5-yl)ethanoic acid, Glutamate receptor ionotropic, NMDA 2D | | 著者 | Hansen, K.B, Tajima, N, Risgaard, R, Perszyk, R.E, Jorgensen, L, Vance, K.M, Ogden, K.K, Clausen, R.P, Furukawa, H, Traynelis, S.F. | | 登録日 | 2013-03-27 | | 公開日 | 2013-05-29 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors.
Mol.Pharmacol., 84, 2013
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