5T0N
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6X93
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![BU of 6x93 by Molmil](/molmil-images/mine/6x93) | Interleukin-10 signaling complex with IL-10RA and IL-10RB | 分子名称: | Interleukin-10, Interleukin-10 receptor subunit alpha, Interleukin-10 receptor subunit beta | 著者 | Saxton, R.A, Tsutsumi, N, Gati, C, Garcia, K.C. | 登録日 | 2020-06-02 | 公開日 | 2021-03-17 | 最終更新日 | 2021-03-31 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10. Science, 371, 2021
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5DJ4
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5I2C
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6WEO
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![BU of 6weo by Molmil](/molmil-images/mine/6weo) | IL-22 Signaling Complex with IL-22R1 and IL-10Rbeta | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Saxton, R.A, Jude, K.M, Henneberg, L.T, Garcia, K.C. | 登録日 | 2020-04-02 | 公開日 | 2021-04-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design. Immunity, 54, 2021
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8DHA
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8DH8
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8DH9
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8EWY
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![BU of 8ewy by Molmil](/molmil-images/mine/8ewy) | Structure of Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain | 分子名称: | ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, Interferon lambda receptor 1, ... | 著者 | Caveney, N.A, Saxton, R.A, Waghray, D, Garcia, K.C. | 登録日 | 2022-10-24 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-22 | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | 主引用文献 | Structural basis of Janus kinase trans-activation. Cell Rep, 42, 2023
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8TLD
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7T6F
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![BU of 7t6f by Molmil](/molmil-images/mine/7t6f) | Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain | 分子名称: | ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, Interferon lambda receptor 1, ... | 著者 | Glassman, C.R, Tsutsumi, N, Jude, K.M, Garcia, K.C. | 登録日 | 2021-12-13 | 公開日 | 2022-03-16 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation. Science, 376, 2022
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7UHY
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![BU of 7uhy by Molmil](/molmil-images/mine/7uhy) | Human GATOR2 complex | 分子名称: | GATOR complex protein MIOS, GATOR complex protein WDR24, GATOR complex protein WDR59, ... | 著者 | Rogala, K.B, Valenstein, M.L, Lalgudi, P.V. | 登録日 | 2022-03-27 | 公開日 | 2022-07-20 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Structure of the nutrient-sensing hub GATOR2. Nature, 607, 2022
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6MOH
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![BU of 6moh by Molmil](/molmil-images/mine/6moh) | Dimeric DARPin C_R3 complex with EpoR | 分子名称: | Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ... | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOI
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![BU of 6moi by Molmil](/molmil-images/mine/6moi) | Dimeric DARPin C_angle_R5 complex with EpoR | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Dimeric DARPing CCR5 (C_angle_R5), ... | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.065 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOG
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![BU of 6mog by Molmil](/molmil-images/mine/6mog) | Dimeric DARPin C_R3 | 分子名称: | 1,2-ETHANEDIOL, DARPin C_R3, TRIETHYLENE GLYCOL | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOJ
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![BU of 6moj by Molmil](/molmil-images/mine/6moj) | Dimeric DARPin A_angle_R5 complex with EpoR | 分子名称: | D(-)-TARTARIC ACID, Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, ... | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.431 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOK
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![BU of 6mok by Molmil](/molmil-images/mine/6mok) | Dimeric DARPin A_distance_R7 complex with EpoR | 分子名称: | Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (5.101 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOE
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![BU of 6moe by Molmil](/molmil-images/mine/6moe) | Monomeric DARPin E2 complex with EpoR | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E2 DARPin, ... | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOL
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![BU of 6mol by Molmil](/molmil-images/mine/6mol) | Monoextended DARPin M_R12 complex with EpoR | 分子名称: | Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12) | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.163 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOF
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![BU of 6mof by Molmil](/molmil-images/mine/6mof) | Monomeric DARPin G2 complex with EpoR | 分子名称: | 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.894 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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8ENT
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![BU of 8ent by Molmil](/molmil-images/mine/8ent) | Interleukin-21 signaling complex with IL-21R and IL-2Rg | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Abhiraman, G.C, Jude, K.M, Garcia, K.C. | 登録日 | 2022-09-30 | 公開日 | 2023-06-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | A structural blueprint for interleukin-21 signal modulation. Cell Rep, 42, 2023
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