5T0N
 
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6X93
 | | Interleukin-10 signaling complex with IL-10RA and IL-10RB | | 分子名称: | Interleukin-10, Interleukin-10 receptor subunit alpha, Interleukin-10 receptor subunit beta | | 著者 | Saxton, R.A, Tsutsumi, N, Gati, C, Garcia, K.C. | | 登録日 | 2020-06-02 | | 公開日 | 2021-03-17 | | 最終更新日 | 2021-03-31 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.
Science, 371, 2021
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5DJ4
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5I2C
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6WEO
 | | IL-22 Signaling Complex with IL-22R1 and IL-10Rbeta | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Saxton, R.A, Jude, K.M, Henneberg, L.T, Garcia, K.C. | | 登録日 | 2020-04-02 | | 公開日 | 2021-04-28 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design.
Immunity, 54, 2021
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8DHA
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8DH8
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8DH9
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8EWY
 | | Structure of Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain | | 分子名称: | ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, Interferon lambda receptor 1, ... | | 著者 | Caveney, N.A, Saxton, R.A, Waghray, D, Garcia, K.C. | | 登録日 | 2022-10-24 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-03-22 | | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | | 主引用文献 | Structural basis of Janus kinase trans-activation.
Cell Rep, 42, 2023
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8TLD
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7T6F
 | | Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain | | 分子名称: | ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, Interferon lambda receptor 1, ... | | 著者 | Glassman, C.R, Tsutsumi, N, Jude, K.M, Garcia, K.C. | | 登録日 | 2021-12-13 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.
Science, 376, 2022
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7UHY
 | | Human GATOR2 complex | | 分子名称: | GATOR complex protein MIOS, GATOR complex protein WDR24, GATOR complex protein WDR59, ... | | 著者 | Rogala, K.B, Valenstein, M.L, Lalgudi, P.V. | | 登録日 | 2022-03-27 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-08-03 | | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | | 主引用文献 | Structure of the nutrient-sensing hub GATOR2.
Nature, 607, 2022
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6MOH
 | | Dimeric DARPin C_R3 complex with EpoR | | 分子名称: | Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ... | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOI
 | | Dimeric DARPin C_angle_R5 complex with EpoR | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Dimeric DARPing CCR5 (C_angle_R5), ... | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.065 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOG
 | | Dimeric DARPin C_R3 | | 分子名称: | 1,2-ETHANEDIOL, DARPin C_R3, TRIETHYLENE GLYCOL | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOJ
 | | Dimeric DARPin A_angle_R5 complex with EpoR | | 分子名称: | D(-)-TARTARIC ACID, Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, ... | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.431 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOK
 | | Dimeric DARPin A_distance_R7 complex with EpoR | | 分子名称: | Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (5.101 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOE
 | | Monomeric DARPin E2 complex with EpoR | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E2 DARPin, ... | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOL
 | | Monoextended DARPin M_R12 complex with EpoR | | 分子名称: | Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12) | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.163 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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6MOF
 | | Monomeric DARPin G2 complex with EpoR | | 分子名称: | 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.894 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
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8ENT
 | | Interleukin-21 signaling complex with IL-21R and IL-2Rg | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Abhiraman, G.C, Jude, K.M, Garcia, K.C. | | 登録日 | 2022-09-30 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | A structural blueprint for interleukin-21 signal modulation.
Cell Rep, 42, 2023
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