1LLS
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![BU of 1lls by Molmil](/molmil-images/mine/1lls) | CRYSTAL STRUCTURE OF UNLIGANDED MALTOSE BINDING PROTEIN WITH XENON | 分子名称: | Maltose-binding periplasmic protein, XENON | 著者 | Rubin, S.M, Lee, S.-Y, Ruiz, E.J, Pines, A, Wemmer, D.E. | 登録日 | 2002-04-30 | 公開日 | 2002-09-18 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | DETECTION AND CHARACTERIZATION OF XENON-BINDING SITES IN PROTEINS BY 129XE NMR SPECTROSCOPY J.MOL.BIOL., 322, 2002
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1PA4
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![BU of 1pa4 by Molmil](/molmil-images/mine/1pa4) | Solution structure of a putative ribosome-binding factor from Mycoplasma pneumoniae (MPN156) | 分子名称: | Probable ribosome-binding factor A | 著者 | Rubin, S.M, Pelton, J.G, Yokota, H, Kim, R, Wemmer, D.E, Berkeley Structural Genomics Center (BSGC) | 登録日 | 2003-05-13 | 公開日 | 2004-03-02 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a putative ribosome binding protein from Mycoplasma pneumoniae and comparison to a distant homolog. J.STRUCT.FUNCT.GENOM., 4, 2003
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2AZE
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![BU of 2aze by Molmil](/molmil-images/mine/2aze) | Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer | 分子名称: | Retinoblastoma-associated protein, Transcription factor Dp-1, Transcription factor E2F1 | 著者 | Rubin, S.M, Gall, A.L, Zheng, N, Pavletich, N.P. | 登録日 | 2005-09-10 | 公開日 | 2006-01-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell(Cambridge,Mass.), 123, 2005
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7SMD
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![BU of 7smd by Molmil](/molmil-images/mine/7smd) | p107 pocket domain complexed with EID1 peptide | 分子名称: | EP300-interacting inhibitor of differentiation 1, Retinoblastoma-like protein 1, SULFATE ION | 著者 | Putta, S, Fernandez, S.M, Tripathi, S.M, Muller, G.A, Rubin, S.M. | 登録日 | 2021-10-25 | 公開日 | 2022-06-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family. Structure, 30, 2022
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7SME
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![BU of 7sme by Molmil](/molmil-images/mine/7sme) | p107 pocket domain complexed with HDAC1 peptide | 分子名称: | Histone deacetylase 1, Retinoblastoma-like protein 1, SULFATE ION | 著者 | Putta, S, Fernandez, S.M, Tripathi, S.M, Muller, G.A, Rubin, S.M. | 登録日 | 2021-10-25 | 公開日 | 2022-06-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family. Structure, 30, 2022
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7SMF
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![BU of 7smf by Molmil](/molmil-images/mine/7smf) | p107 pocket domain complexed with mutated HDAC1-3X peptide | 分子名称: | Histone deacetylase 1, Retinoblastoma-like protein 1, SULFATE ION | 著者 | Putta, S, Fernandez, S.M, Tripathi, S.M, Muller, G.A, Rubin, S.M. | 登録日 | 2021-10-25 | 公開日 | 2022-06-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family. Structure, 30, 2022
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7SMC
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![BU of 7smc by Molmil](/molmil-images/mine/7smc) | p107 pocket domain complexed with ARID4A peptide | 分子名称: | AT-rich interactive domain-containing protein 4A, Retinoblastoma-like protein 1, SULFATE ION | 著者 | Putta, S, Fernandez, S.M, Tripathi, S.M, Muller, G.A, Rubin, S.M. | 登録日 | 2021-10-25 | 公開日 | 2022-06-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family. Structure, 30, 2022
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7N40
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![BU of 7n40 by Molmil](/molmil-images/mine/7n40) | Crystal structure of LIN9-RbAp48-LIN37, a MuvB subcomplex | 分子名称: | Histone-binding protein RBBP4, Isoform 2 of Protein lin-9 homolog, Protein lin-37 homolog | 著者 | Asthana, A, Ramanan, P, Tripathi, S.M, Rubin, S.M. | 登録日 | 2021-06-02 | 公開日 | 2022-02-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes. Nat Commun, 13, 2022
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5FD3
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![BU of 5fd3 by Molmil](/molmil-images/mine/5fd3) | Structure of Lin54 tesmin domain bound to DNA | 分子名称: | DNA (5'-D(*CP*AP*GP*TP*TP*TP*CP*AP*AP*AP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*TP*TP*TP*GP*AP*AP*AP*CP*T)-3'), Protein lin-54 homolog, ... | 著者 | Marceau, A.H, Felthousen, J.G, Goetsch, P.D, Lee, H, Tripathi, S.M, Strome, S, Litovchick, L, Rubin, S.M. | 登録日 | 2015-12-15 | 公開日 | 2016-08-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Structural basis for LIN54 recognition of CHR elements in cell cycle-regulated promoters. Nat Commun, 7, 2016
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8CUR
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![BU of 8cur by Molmil](/molmil-images/mine/8cur) | Crystal structure of Cdk2 in complex with Cyclin A inhibitor 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid | 分子名称: | 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid, Cyclin-dependent kinase 2 | 著者 | Tripathi, S.M, Tambo, C.S, Kiss, G, Rubin, S.M. | 登録日 | 2022-05-17 | 公開日 | 2023-04-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics. Acs Chem.Biol., 18, 2023
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6C48
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![BU of 6c48 by Molmil](/molmil-images/mine/6c48) | Crystal structure of B-Myb-LIN9-LIN52 complex | 分子名称: | Myb-related protein B, Protein lin-52 homolog, Protein lin-9 homolog, ... | 著者 | Guiley, K.Z, Tripathi, S.M, Rubin, S.M. | 登録日 | 2018-01-11 | 公開日 | 2018-09-19 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Structural mechanism of Myb-MuvB assembly. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6P8F
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![BU of 6p8f by Molmil](/molmil-images/mine/6p8f) | Crystal structure of CDK4 in complex with CyclinD1 and P27 | 分子名称: | Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1B, G1/S-specific cyclin-D1 | 著者 | Guiley, K.Z, Stevenson, J.W, Lou, K, Barkovich, K.J, Bunch, K, Tripathi, S.M, Shokat, K.M, Rubin, S.M. | 登録日 | 2019-06-07 | 公開日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science, 366, 2019
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6P8H
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![BU of 6p8h by Molmil](/molmil-images/mine/6p8h) | Crystal structure of CDK4 in complex with CyclinD1 and P21 | 分子名称: | Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1, G1/S-specific cyclin-D1 | 著者 | Guiley, K.Z, Stevenson, J.W, Lou, K, Barkovich, K.J, Bunch, K, Tripathi, S.M, Shokat, K.M, Rubin, S.M. | 登録日 | 2019-06-07 | 公開日 | 2019-12-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science, 366, 2019
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6P8G
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![BU of 6p8g by Molmil](/molmil-images/mine/6p8g) | Crystal structure of CDK4 in complex with CyclinD1 and P27 | 分子名称: | Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1B, G1/S-specific cyclin-D1 | 著者 | Guiley, K.Z, Stevenson, J.W, Lou, K, Barkovich, K.J, Bunch, K, Tripathi, S.M, Shokat, K.M, Rubin, S.M. | 登録日 | 2019-06-07 | 公開日 | 2019-12-25 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science, 366, 2019
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6P8E
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![BU of 6p8e by Molmil](/molmil-images/mine/6p8e) | Crystal structure of CDK4 in complex with CyclinD1 and P27 | 分子名称: | Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1B, G1/S-specific cyclin-D1, ... | 著者 | Guiley, K.Z, Stevenson, J.W, Lou, K, Barkovich, K.J, Bunch, K, Tripathi, S.M, Shokat, K.M, Rubin, S.M. | 登録日 | 2019-06-07 | 公開日 | 2019-12-25 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science, 366, 2019
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5C9H
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![BU of 5c9h by Molmil](/molmil-images/mine/5c9h) | Structural Basis of Template Boundary Definition in Tetrahymena Telomerase | 分子名称: | MAGNESIUM ION, RNA (5'-R(P*AP*GP*AP*AP*CP*UP*GP*UP*CP*A)-3'), RNA (5'-R(P*UP*CP*AP*UP*UP*CP*AP*GP*UP*UP*CP*U)-3'), ... | 著者 | Jansson, L.I, Akiyama, B.M, Ooms, A, Lu, C, Rubin, S.M, Stone, M.D. | 登録日 | 2015-06-26 | 公開日 | 2015-10-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis of template-boundary definition in Tetrahymena telomerase. Nat.Struct.Mol.Biol., 22, 2015
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6U1Q
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![BU of 6u1q by Molmil](/molmil-images/mine/6u1q) | Crystal Structure of VpsO (VC0937) Kinase domain | 分子名称: | O-PHOSPHOTYROSINE, VpsO | 著者 | Tripathi, S.M, Schwechheimer, C, Herbert, K, Porcella, M.E, Brown, E.R, Yildiz, F.H, Rubin, S.M. | 登録日 | 2019-08-16 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae. Plos Pathog., 16, 2020
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6U1P
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![BU of 6u1p by Molmil](/molmil-images/mine/6u1p) | Crystal structure of VpsU (VC0916) from Vibrio cholerae | 分子名称: | GLYCEROL, Low molecular weight phosphotyrosine protein phosphatase | 著者 | Tripathi, S.M, Schwechheimer, C, Herbert, K, Osorio, J, Yildiz, F.H, Rubin, S.M. | 登録日 | 2019-08-16 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | 主引用文献 | A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae. Plos Pathog., 16, 2020
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6OSW
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![BU of 6osw by Molmil](/molmil-images/mine/6osw) | An order-to-disorder structural switch activates the FoxM1 transcription factor | 分子名称: | Forkhead box M1 | 著者 | Marceau, A.H, Rubin, S.M, Nerli, S, McShane, A.C, Sgourakis, N.G. | 登録日 | 2019-05-02 | 公開日 | 2019-05-29 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | An order-to-disorder structural switch activates the FoxM1 transcription factor. Elife, 8, 2019
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4LPA
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![BU of 4lpa by Molmil](/molmil-images/mine/4lpa) | Crystal structure of a Cdc6 phosphopeptide in complex with Cks1 | 分子名称: | Cyclin-dependent kinases regulatory subunit | 著者 | McGrath, D.A, Balog, E.R.M, Koivomagi, M, Lucena, R, Mai, M.V, Hirschi, A, Kellogg, D.R, Loog, M, Rubin, S.M. | 登録日 | 2013-07-15 | 公開日 | 2013-11-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Cks confers specificity to phosphorylation-dependent CDK signaling pathways. Nat.Struct.Mol.Biol., 20, 2013
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3POM
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![BU of 3pom by Molmil](/molmil-images/mine/3pom) | |
3N5U
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![BU of 3n5u by Molmil](/molmil-images/mine/3n5u) | Crystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1 | 分子名称: | CHLORIDE ION, MANGANESE (II) ION, Retinoblastoma-associated protein, ... | 著者 | Hirschi, A.M, Cecchini, M, Steinhardt, R.C, Dick, F.A, Rubin, S.M. | 登録日 | 2010-05-25 | 公開日 | 2010-08-11 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein. Nat.Struct.Mol.Biol., 17, 2010
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3QY2
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![BU of 3qy2 by Molmil](/molmil-images/mine/3qy2) | Crystal structure of the P93A monomer mutant of S. cerevisiae Cks1 | 分子名称: | CITRATE ANION, Cyclin-dependent kinases regulatory subunit | 著者 | Balog, E.R.M, Saetern, O.C, Finch, W, Hoeft, C.O, Thai, V, Harvey, S.L, Kellogg, D.K, Rubin, S.M. | 登録日 | 2011-03-02 | 公開日 | 2011-06-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | The structure of a monomeric mutant cks protein reveals multiple functions for a conserved hinge-region proline. J.Mol.Biol., 411, 2011
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4YOS
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![BU of 4yos by Molmil](/molmil-images/mine/4yos) | p107 pocket domain complexed with LIN52 peptide | 分子名称: | 1,2-ETHANEDIOL, Protein lin-52 homolog, Retinoblastoma-like protein 1,Retinoblastoma-like protein 1, ... | 著者 | Guiley, K.Z, Liban, T.J, Felthousen, J.G, Ramanan, P, Tripathi, S, Litovchick, L, Rubin, S.M. | 登録日 | 2015-03-12 | 公開日 | 2015-05-27 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural mechanisms of DREAM complex assembly and regulation. Genes Dev., 29, 2015
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4YOZ
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![BU of 4yoz by Molmil](/molmil-images/mine/4yoz) | p107 pocket domain in complex with HPV E7 peptide | 分子名称: | HPV E7 peptide, Retinoblastoma-like protein 1,Retinoblastoma-like protein 1, SULFATE ION | 著者 | Liban, T.J, Guiley, K.Z, Felthousen, J.G, Ramanan, P, Litovchick, L, Rubin, S.M. | 登録日 | 2015-03-12 | 公開日 | 2015-06-24 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.245 Å) | 主引用文献 | Structural mechanisms of DREAM complex assembly and regulation. Genes Dev., 29, 2015
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