6P8H

Crystal structure of CDK4 in complex with CyclinD1 and P21

Summary for 6P8H

DescriptorG1/S-specific cyclin-D1, Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1 (3 entities in total)
Functional Keywordscyclin-dependent kinase, kinase inhibitor, cell cycle, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight71480.49
Authors
Primary citation
Guiley, K.Z.,Stevenson, J.W.,Lou, K.,Barkovich, K.J.,Kumarasamy, V.,Wijeratne, T.U.,Bunch, K.L.,Tripathi, S.,Knudsen, E.S.,Witkiewicz, A.K.,Shokat, K.M.,Rubin, S.M.
p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.
Science, 366:-, 2019
PubMed: 31831640 (PDB entries with the same primary citation)
DOI: 10.1126/science.aaw2106
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.19 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2606 1.1% 2.3% 0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload