6P8H
Crystal structure of CDK4 in complex with CyclinD1 and P21
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | G1/S-specific cyclin-D1 | polymer | 249 | 28445.3 | 1 | UniProt (P24385) Pfam (PF00134) Pfam (PF02984) In PDB | Homo sapiens (Human) | B-cell lymphoma 1 protein,BCL-1,BCL-1 oncogene,PRAD1 oncogene |
| 2 | B | Cyclin-dependent kinase 4 | polymer | 302 | 33947.9 | 1 | UniProt (P11802) Pfam (PF00069) In PDB | Homo sapiens (Human) | Cell division protein kinase 4,PSK-J3 |
| 3 | C | Cyclin-dependent kinase inhibitor 1 | polymer | 80 | 9087.3 | 1 | UniProt (P38936) Pfam (PF02234) In PDB | Homo sapiens (Human) | CDK-interacting protein 1,Melanoma differentiation-associated protein 6,MDA-6,p21 |
Sequence modifications
B: 2 - 300 (UniProt: P11802)
C: 9 - 85 (UniProt: P38936)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Glu 0 | - | expression tag |
| Phe 1 | - | expression tag |
| - | Gly 42 | deletion |
| - | Gly 43 | deletion |
| - | Gly 44 | deletion |
| Glu 43 | Gly 46 | conflict |
| Glu 44 | Gly 47 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 6 | - | expression tag |
| Glu 7 | - | expression tag |
| Phe 8 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 71480.5 | |
| All* | Total formula weight | 71480.5 |
