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6P8H

Crystal structure of CDK4 in complex with CyclinD1 and P21

Functional Information from GO Data
ChainGOidnamespacecontents
B0000082biological_processG1/S transition of mitotic cell cycle
B0000166molecular_functionnucleotide binding
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0000785cellular_componentchromatin
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005667cellular_componenttranscription regulator complex
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005923cellular_componentbicellular tight junction
B0006468biological_processprotein phosphorylation
B0007165biological_processsignal transduction
B0008284biological_processpositive regulation of cell population proliferation
B0009410biological_processresponse to xenobiotic stimulus
B0010389biological_processregulation of G2/M transition of mitotic cell cycle
B0010468biological_processregulation of gene expression
B0010971biological_processpositive regulation of G2/M transition of mitotic cell cycle
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
B0016740molecular_functiontransferase activity
B0030332molecular_functioncyclin binding
B0031965cellular_componentnuclear membrane
B0048146biological_processpositive regulation of fibroblast proliferation
B0051301biological_processcell division
B0051726biological_processregulation of cell cycle
B0060260biological_processregulation of transcription initiation by RNA polymerase II
B0061469biological_processregulation of type B pancreatic cell proliferation
B0071222biological_processcellular response to lipopolysaccharide
B0071353biological_processcellular response to interleukin-4
B0097128cellular_componentcyclin D1-CDK4 complex
B0097129cellular_componentcyclin D2-CDK4 complex
B0097130cellular_componentcyclin D3-CDK4 complex
B0106310molecular_functionprotein serine kinase activity
B1904628biological_processcellular response to phorbol 13-acetate 12-myristate
B1904637biological_processcellular response to ionomycin
C0004861molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity
C0005634cellular_componentnucleus
C0007346biological_processregulation of mitotic cell cycle
C0051726biological_processregulation of cell cycle
C0072331biological_processsignal transduction by p53 class mediator
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGVGAYGTVYkArdphsghf..........VALK
ChainResidueDetails
BILE12-LYS35

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNILV
ChainResidueDetails
BILE133-VAL145

site_idPS00292
Number of Residues32
DetailsCYCLINS Cyclins signature. RkiVatWMlevceeqkCeeevFplAMnYLDRF
ChainResidueDetails
AARG57-PHE88

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues124
DetailsDomain: {"description":"Cyclin N-terminal"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsRegion: {"description":"Required for binding D-type cyclins"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues7
DetailsRegion: {"description":"Required for binding cyclins"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues5
DetailsRegion: {"description":"Required for binding CDKs"}
ChainResidueDetails

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PDB entries from 2025-07-30

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