4XBX
 
 | | Crystal Structure of the L74F/M78F/L103V/L114V/I116V/F139V/L147V mutant of LEH | | 分子名称: | Limonene-1,2-epoxide hydrolase | | 著者 | Kong, X.D, Sun, Z, Xu, J.H, Reetz, M.T, Zhou, J. | | 登録日 | 2014-12-17 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution
Angew.Chem.Int.Ed.Engl., 54, 2015
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4XBT
 | | Crystal Structure of the L74F/M78F/L103V/L114V/I116V/F139V/L147V mutant of LEH complexed with (S,S)-cyclohexanediol | | 分子名称: | (1S,2S)-cyclohexane-1,2-diol, CITRATE ANION, Limonene-1,2-epoxide hydrolase | | 著者 | Kong, X.D, Sun, Z, Lonsdale, R, Xu, J.H, Reetz, M.T, Zhou, J. | | 登録日 | 2014-12-17 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution
Angew.Chem.Int.Ed.Engl., 54, 2015
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4XDV
 | | Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH complexed with cyclohexanediol | | 分子名称: | (1R,2R)-cyclohexane-1,2-diol, Limonene-1,2-epoxide hydrolase | | 著者 | Kong, X.D, Sun, Z, Lonsdale, R, Xu, J.H, Reetz, M.T, Zhou, J. | | 登録日 | 2014-12-20 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution
Angew.Chem.Int.Ed.Engl., 54, 2015
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4XBY
 | | Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH complexed with cyclopentene oxide | | 分子名称: | (1R,5S)-6-oxabicyclo[3.1.0]hexane, Limonene-1,2-epoxide hydrolase | | 著者 | Kong, X.D, Sun, Z, Xu, J.H, Reetz, M.T, Zhou, J. | | 登録日 | 2014-12-17 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution
Angew.Chem.Int.Ed.Engl., 54, 2015
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4XDW
 | | Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH | | 分子名称: | Limonene-1,2-epoxide hydrolase | | 著者 | Kong, X.D, Sun, Z, Lonsdale, R, Xu, J.H, Reetz, M.T, Zhou, J. | | 登録日 | 2014-12-20 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution
Angew.Chem.Int.Ed.Engl., 54, 2015
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5GKW
 | | crystal structure of SZ529 complex with (R,R)-cyclopentanediol | | 分子名称: | (1~{R},2~{R})-cyclopentane-1,2-diol, Limonene-1,2-epoxide hydrolase | | 著者 | Wu, L, Sun, Z.T, Reetz, M.T, Zhou, J.H. | | 登録日 | 2016-07-07 | | 公開日 | 2017-07-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | crystal structure of SZ529 complex with (R,R)-cyclopentanediol
To Be Published
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6LY4
 | | The crystal structure of the BM3 mutant LG-23 in complex with testosterone | | 分子名称: | 1,2-ETHANEDIOL, Bifunctional cytochrome P450/NADPH--P450 reductase, IMIDAZOLE, ... | | 著者 | Peng, Y, Chen, J, Zhou, J, Li, A, ReetZ, M.T. | | 登録日 | 2020-02-13 | | 公開日 | 2020-04-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Regio- and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants.
Angew.Chem.Int.Ed.Engl., 59, 2020
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5YAO
 | | The complex structure of SZ529 and expoxid | | 分子名称: | (1R,5S)-6-oxabicyclo[3.1.0]hexane, Limonene-1,2-epoxide hydrolase, SODIUM ION | | 著者 | Lian, W, Sun, Z.T, Zhou, J.H, Reetz, M.T. | | 登録日 | 2017-09-01 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.611 Å) | | 主引用文献 | Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations
J. Am. Chem. Soc., 140, 2018
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5YNG
 | | Crystal structure of SZ348 in complex with cyclopentene oxide | | 分子名称: | (1R,5S)-6-oxabicyclo[3.1.0]hexane, Limonene-1,2-epoxide hydrolase, NICKEL (II) ION, ... | | 著者 | Wu, L, Sun, Z.T, Reetz, M.T, Zhou, J.H. | | 登録日 | 2017-10-24 | | 公開日 | 2018-06-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | | 主引用文献 | Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations.
J. Am. Chem. Soc., 140, 2018
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5YQT
 | | Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH complexed with cyclopentene oxide | | 分子名称: | (1R,5S)-6-oxabicyclo[3.1.0]hexane, Limonene-1,2-epoxide hydrolase | | 著者 | Kong, X.D, Sun, Z.T, Wu, L, Reetz, M.T, Zhou, J.H, Xu, J.H. | | 登録日 | 2017-11-07 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations.
J. Am. Chem. Soc., 140, 2018
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3QZU
 | | Crystal structure of Bacillus subtilis Lipase A 7-fold mutant; the outcome of directed evolution towards thermostability | | 分子名称: | CHLORIDE ION, GLYCEROL, Lipase estA, ... | | 著者 | Pijning, T, Augustyniak, W, Reetz, M.T, Dijkstra, B.W. | | 登録日 | 2011-03-07 | | 公開日 | 2012-02-08 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Biophysical characterization of mutants of Bacillus subtilis lipase evolved for thermostability: Factors contributing to increased activity retention.
Protein Sci., 21, 2012
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5JPU
 | | Structure of limonene epoxide hydrolase mutant - H-2-H5 complex with (S,S)-cyclohexane-1,2-diol | | 分子名称: | (1S,2S)-cyclohexane-1,2-diol, limonene epoxide hydrolase | | 著者 | Li, G, Zhang, H, Sun, Z, Liu, X, Reetz, M.T. | | 登録日 | 2016-05-04 | | 公開日 | 2016-06-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Multi-Parameter Optimization in Directed Evolution: Engineering Thermostability, Enantioselectivity and Activity of an Epoxide Hydrolase
To be published
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5JPP
 | | Structure of limonene epoxide hydrolase mutant - H-2-H5 | | 分子名称: | limonene epoxide hydrolase | | 著者 | Li, G, Zhang, H, Sun, Z, Liu, X, Reetz, M.T. | | 登録日 | 2016-05-04 | | 公開日 | 2016-06-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Multi-Parameter Optimization in Directed Evolution: Engineering Thermostability, Enantioselectivity and Activity of an Epoxide Hydrolase
To be published
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1R4Z
 | | Bacillus subtilis lipase A with covalently bound Rc-IPG-phosphonate-inhibitor | | 分子名称: | Lipase, [(4R)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YL]METHYL HYDROGEN HEX-5-ENYLPHOSPHONATE | | 著者 | Droege, M.J, Van Pouderoyen, G, Vrenken, T.E, Rueggeberg, C.J, Reetz, M.T, Dijkstra, B.W, Quax, W.J. | | 登録日 | 2003-10-09 | | 公開日 | 2004-10-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Directed Evolution of Bacillus subtilis Lipase A by Use of Enantiomeric Phosphonate Inhibitors: Crystal Structures and Phage Display Selection
Chembiochem, 7, 2005
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1R50
 | | Bacillus subtilis lipase A with covalently bound Sc-IPG-phosphonate-inhibitor | | 分子名称: | Lipase, [(4S)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YL]METHYL HYDROGEN HEX-5-ENYLPHOSPHONATE | | 著者 | Droege, M.J, Van Pouderoyen, G, Vrenken, T.E, Rueggeberg, C.J, Reetz, M.T, Dijkstra, B.W, Quax, W.J. | | 登録日 | 2003-10-09 | | 公開日 | 2004-10-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Directed Evolution of Bacillus subtilis Lipase A by Use of Enantiomeric Phosphonate Inhibitors: Crystal Structures and Phage Display Selection
Chembiochem, 7, 2005
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5CK6
 | | Crystal structure of SZ348 in complex with cyclopentene oxide | | 分子名称: | (1R,5S)-6-oxabicyclo[3.1.0]hexane, Limonene-1,2-epoxide hydrolase, NICKEL (II) ION, ... | | 著者 | Wu, L, Sun, Z.T, Reetz, M.T, Zhou, J.H. | | 登録日 | 2015-07-15 | | 公開日 | 2016-07-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of SZ348 in complex with cyclopentene oxide
To Be Published
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5CLK
 | | Crystal structure of SZ348 in complex with S,S-cyclohexanediol | | 分子名称: | (1S,2S)-cyclohexane-1,2-diol, CHLORIDE ION, Limonene-1,2-epoxide hydrolase, ... | | 著者 | Wu, L, Sun, Z.T, Reetz, M.T, Zhou, J.H. | | 登録日 | 2015-07-16 | | 公開日 | 2016-07-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | | 主引用文献 | Crystal structure of SZ348 in complex with S,S-cyclohexanediol
To Be Published
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5CF1
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5CF2
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3G02
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3G0I
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5OG9
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6ISQ
 | | structure of Lipase mutant with oxided Cys-His-Asp catalytic triad | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, ISOPROPYL ALCOHOL, ... | | 著者 | Cen, Y.X, Zhou, J.H, Wu, Q. | | 登録日 | 2018-11-18 | | 公開日 | 2019-07-24 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution.
Nat Commun, 10, 2019
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6ISR
 | | structure of lipase mutant with Cys-His-Asp catalytic triad | | 分子名称: | DI(HYDROXYETHYL)ETHER, Lipase B, NICKEL (II) ION, ... | | 著者 | Cen, Y.X, Zhou, J.H, Wu, Q. | | 登録日 | 2018-11-18 | | 公開日 | 2019-07-24 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution.
Nat Commun, 10, 2019
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6ISP
 | | structure of Candida antarctica Lipase B mutant | | 分子名称: | CALCIUM ION, Lipase B, N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE | | 著者 | Cen, Y.X, Zhou, J.H, Wu, Q. | | 登録日 | 2018-11-18 | | 公開日 | 2019-07-24 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution.
Nat Commun, 10, 2019
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