4XDV

Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH complexed with cyclohexanediol

Summary for 4XDV

Entry DOI	10.2210/pdb4xdv/pdb
Related	4xbt 4xbx 4xby 4xdw
Descriptor	Limonene-1,2-epoxide hydrolase, (1R,2R)-cyclohexane-1,2-diol (3 entities in total)
Functional Keywords	epoxide hydrolase, hydrolase
Biological source	Rhodococcus erythropolis
Total number of polymer chains	8
Total formula weight	139419.68
Authors	Kong, X.D.,Sun, Z.,Lonsdale, R.,Xu, J.H.,Reetz, M.T.,Zhou, J. (deposition date: 2014-12-20, release date: 2015-07-15, Last modification date: 2024-03-20)
Primary citation	Sun, Z.,Lonsdale, R.,Kong, X.D.,Xu, J.H.,Zhou, J.,Reetz, M.T. Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution Angew.Chem.Int.Ed.Engl., 54:12410-12415, 2015 Cited by PubMed: 25891639 DOI: 10.1002/anie.201501809 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation