4XBT

Crystal Structure of the L74F/M78F/L103V/L114V/I116V/F139V/L147V mutant of LEH complexed with (S,S)-cyclohexanediol

Summary for 4XBT

Entry DOI	10.2210/pdb4xbt/pdb
Related	4XBX 4XBY 4XDV 4XDW
Descriptor	Limonene-1,2-epoxide hydrolase, (1S,2S)-cyclohexane-1,2-diol, CITRATE ANION, ... (4 entities in total)
Functional Keywords	epoxide hydrolase, product complex, hydrolase
Biological source	Rhodococcus erythropolis
Total number of polymer chains	4
Total formula weight	69847.74
Authors	Kong, X.D.,Sun, Z.,Lonsdale, R.,Xu, J.H.,Reetz, M.T.,Zhou, J. (deposition date: 2014-12-17, release date: 2015-07-15, Last modification date: 2023-11-08)
Primary citation	Sun, Z.,Lonsdale, R.,Kong, X.D.,Xu, J.H.,Zhou, J.,Reetz, M.T. Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution Angew.Chem.Int.Ed.Engl., 54:12410-12415, 2015 Cited by PubMed: 25891639 DOI: 10.1002/anie.201501809 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation