6S8M
 
 | | S. pombe microtubule decorated with Cut7 motor domain in the AMPPNP state | | 分子名称: | 7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Moores, C.A, von Loeffelholz, O. | | 登録日 | 2019-07-10 | | 公開日 | 2019-08-21 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Cryo-EM Structure (4.5- angstrom ) of Yeast Kinesin-5-Microtubule Complex Reveals a Distinct Binding Footprint and Mechanism of Drug Resistance.
J.Mol.Biol., 431, 2019
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8P94
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7Z2A
 | | P. berghei kinesin-8B motor domain in no nucleotide state bound to tubulin dimer | | 分子名称: | Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ... | | 著者 | Liu, T, Shilliday, F, Cook, A.D, Moores, C.A. | | 登録日 | 2022-02-26 | | 公開日 | 2022-10-19 | | 最終更新日 | 2022-11-30 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
Nat Commun, 13, 2022
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7Z2C
 | | P. falciparum kinesin-8B motor domain in no nucleotide bound to tubulin dimer | | 分子名称: | Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ... | | 著者 | Liu, T, Shilliday, F, Cook, A.D, Moores, C.A. | | 登録日 | 2022-02-26 | | 公開日 | 2022-10-19 | | 最終更新日 | 2022-11-30 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
Nat Commun, 13, 2022
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7Z2B
 | | P. berghei kinesin-8B motor domain in AMPPNP state bound to tubulin dimer | | 分子名称: | Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ... | | 著者 | Liu, T, Shilliday, F, Cook, A.D, Moores, C.A. | | 登録日 | 2022-02-26 | | 公開日 | 2022-11-16 | | 最終更新日 | 2022-11-30 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
Nat Commun, 13, 2022
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6I2I
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3LRE
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6QUS
 | | HsCKK (human CAMSAP1) decorated 13pf taxol-GDP microtubule | | 分子名称: | Calmodulin-regulated spectrin-associated protein 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A. | | 登録日 | 2019-02-28 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
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6ZPH
 | | Kinesin binding protein complexed with Kif15 motor domain | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, KIF-binding protein, Kinesin-like protein KIF15, ... | | 著者 | Atherton, J, Hummel, J.J.A, Olieric, N, Locke, J, Pena, A, Rosenfeld, S.S, Steinmetz, M.O, Hoogenraad, C.C, Moores, C.A. | | 登録日 | 2020-07-08 | | 公開日 | 2020-12-30 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (6.9 Å) | | 主引用文献 | The mechanism of kinesin inhibition by kinesin-binding protein.
Elife, 9, 2020
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6ZPI
 | | Microtubule complexed with Kif15 motor domain. Symmetrised asymmetric unit | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF15, ... | | 著者 | Atherton, J, Hummel, J.J.A, Olieric, N, Locke, J, Pena, A, Rosenfeld, S.S, Steinmetz, M.O, Hoogenraad, C.C, Moores, C.A. | | 登録日 | 2020-07-08 | | 公開日 | 2020-12-30 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | The mechanism of kinesin inhibition by kinesin-binding protein.
Elife, 9, 2020
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6ZPG
 | | Kinesin binding protein (KBP) | | 分子名称: | KIF-binding protein | | 著者 | Atherton, J, Hummel, J.J.A, Olieric, N, Locke, J, Pena, A, Rosenfeld, S.S, Steinmetz, M.O, Hoogenraad, C.C, Moores, C.A. | | 登録日 | 2020-07-08 | | 公開日 | 2020-12-30 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | The mechanism of kinesin inhibition by kinesin-binding protein.
Elife, 9, 2020
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4ATU
 | | Human doublecortin N-DC repeat plus linker, and tubulin (2XRP) docked into an 8A cryo-EM map of doublecortin-stabilised microtubules reconstructed in absence of kinesin | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, NEURONAL MIGRATION PROTEIN DOUBLECORTIN, ... | | 著者 | Liu, J.S, Schubert, C.R, Fu, X, Fourniol, F.J, Jaiswal, J.K, Houdusse, A, Stultz, C.M, Moores, C.A, Walsh, C.A. | | 登録日 | 2012-05-09 | | 公開日 | 2012-09-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (8.3 Å) | | 主引用文献 | Molecular Basis for Specific Regulation of Neuronal Kinesin- 3 Motors by Doublecortin Family Proteins.
Mol.Cell, 47, 2012
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4ATX
 | | Rigor kinesin motor domain with an ordered neck-linker, docked on tubulin dimer, modelled into the 8A cryo-EM map of doublecortin- microtubules decorated with kinesin | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-1 HEAVY CHAIN, ... | | 著者 | Liu, J.S, Schubert, C.R, Fu, X, Fourniol, F.J, Jaiswal, J.K, Houdusse, A, Stultz, C.M, Moores, C.A, Walsh, C.A. | | 登録日 | 2012-05-10 | | 公開日 | 2012-09-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | | 主引用文献 | Molecular Basis for Specific Regulation of Neuronal Kinesin- 3 Motors by Doublecortin Family Proteins.
Mol.Cell, 47, 2012
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5JCO
 | | Structure and dynamics of single-isoform recombinant neuronal human tubulin | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | 著者 | Vemu, A, Atherton, J, Spector, J.O, Szyk, A, Moores, C.A, Roll-Mecak, A. | | 登録日 | 2016-04-15 | | 公開日 | 2016-05-04 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin.
J.Biol.Chem., 291, 2016
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8RC1
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6TIW
 | | Human kinesin-5 motor domain in the GSK state bound to microtubules (Conformation 2) | | 分子名称: | 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one, Kinesin-like protein KIF11, MAGNESIUM ION, ... | | 著者 | Pena, A, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M. | | 登録日 | 2019-11-22 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure, 28, 2020
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6TA4
 | | Human kinesin-5 motor domain in the AMPPNP state bound to microtubules | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION, ... | | 著者 | Pena, A.P, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M. | | 登録日 | 2019-10-29 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | | 主引用文献 | Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure, 28, 2020
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6TA3
 | | Human kinesin-5 motor domain in the GSK-1 state bound to microtubules (Conformation 1) | | 分子名称: | 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one, Kinesin-like protein KIF11, MAGNESIUM ION, ... | | 著者 | Pena, A, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M. | | 登録日 | 2019-10-29 | | 公開日 | 2020-04-22 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure, 28, 2020
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2XRP
 | | Human Doublecortin N-DC Repeat (1MJD) and Mammalian Tubulin (1JFF and 3HKE) Docked into the 8-Angstrom Cryo-EM Map of Doublecortin- Stabilised Microtubules | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, NEURONAL MIGRATION PROTEIN DOUBLECORTIN, ... | | 著者 | Fourniol, F.J, Sindelar, C.V, Amigues, B, Clare, D.K, Thomas, G, Perderiset, M, Francis, F, Houdusse, A, Moores, C.A. | | 登録日 | 2010-09-18 | | 公開日 | 2010-11-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | | 主引用文献 | Template-Free 13-Protofilament Microtubule-Map Assembly Visualized at 8 A Resolution.
J.Cell Biol., 191, 2010
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6QVJ
 | | HsCKK (human CAMSAP1) decorated 14pf taxol-GDP microtubule | | 分子名称: | Calmodulin-regulated spectrin-associated protein 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A. | | 登録日 | 2019-03-02 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
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6QUY
 | | NgCKK (N.Gruberi CKK) decorated 13pf taxol-GDP microtubule | | 分子名称: | CKK domain protein, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A. | | 登録日 | 2019-02-28 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
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6QVE
 | | NgCKK (Naegleria Gruberi CKK) decorated 14pf taxol-GDP microtubule | | 分子名称: | Beta1-tubulin, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A. | | 登録日 | 2019-03-01 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
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4ABO
 | | Mal3 CH domain homology model and mammalian tubulin (2XRP) docked into the 8.6-Angstrom cryo-EM map of Mal3-GTPgammaS-microtubules | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MICROTUBULE INTEGRITY PROTEIN MAL3, ... | | 著者 | Maurer, S.P, Fourniol, F.J, Bohner, G, Moores, C.A, Surrey, T. | | 登録日 | 2011-12-09 | | 公開日 | 2012-06-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (8.6 Å) | | 主引用文献 | Ebs Recognize a Nucleotide-Dependent Structural CAP at Growing Microtubule Ends.
Cell(Cambridge,Mass.), 149, 2012
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5M5L
 | | Pseudo-atomic model of microtubule-bound S. pombe kinesin-5 motor domain in the AMPPNP state (based on cryo-electron microscopy experiment): the N-terminus adopts multiple conformations | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein cut7, ... | | 著者 | Goulet, A, Moores, C.A, Cross, R.A. | | 登録日 | 2016-10-21 | | 公開日 | 2016-11-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (9.3 Å) | | 主引用文献 | Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5M5I
 | | Pseudo-atomic model of microtubule-bound S.pombe kinesin-5 motor domain in the AMPPNP state (based on cryo-electron microscopy experiment): the N-terminus conformation allows formation of a cover neck bundle. | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein cut7, ... | | 著者 | Goulet, A, Moores, C.A, Cross, R.A. | | 登録日 | 2016-10-21 | | 公開日 | 2016-11-30 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (9.3 Å) | | 主引用文献 | Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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