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5IFH
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BU of 5ifh by Molmil
Crystal structure of the BCR Fab fragment from subset #2 case P11475
分子名称: Heavy chain of the Fab fragment from BCR derived from the P11475 CLL clone, Light chain of the Fab fragment from BCR derived from the P11475 CLL clone
著者Minici, C, Degano, M.
登録日2016-02-26
公開日2017-03-08
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.293 Å)
主引用文献Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia.
Nat Commun, 8, 2017
5DRX
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BU of 5drx by Molmil
Crystal structure of the BCR Fab fragment from subset #4 case CLL240
分子名称: CLL240 BCR light chain, CLL240 heavy chain (VH and CH1 domains), GLYCEROL
著者Minici, C, Degano, M.
登録日2015-09-16
公開日2016-09-28
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.104 Å)
主引用文献Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia.
Nat Commun, 8, 2017
5DRW
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BU of 5drw by Molmil
Crystal structure of the BCR Fab fragment from subset #4 case CLL183
分子名称: CLL183 BCR antibody heavy chain, CLL183 BCR antibody light chain
著者Minici, C, Degano, M.
登録日2015-09-16
公開日2016-09-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia.
Nat Commun, 8, 2017
3T8J
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BU of 3t8j by Molmil
Structural analysis of thermostable S. solfataricus pyrimidine-specific nucleoside hydrolase
分子名称: Purine nucleosidase, (IunH-1), SODIUM ION
著者Minici, C, Cacciapuoti, G, De Leo, E, Porcelli, M, Degano, M.
登録日2011-08-01
公開日2012-05-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献New Determinants in the Catalytic Mechanism of Nucleoside Hydrolases from the Structures of Two Isozymes from Sulfolobus solfataricus.
Biochemistry, 51, 2012
3T8I
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BU of 3t8i by Molmil
Structural analysis of thermostable S. solfataricus purine-specific nucleoside hydrolase
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Minici, C, Cacciapuoti, G, De Leo, E, Porcelli, M, Degano, M.
登録日2011-08-01
公開日2012-05-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献New Determinants in the Catalytic Mechanism of Nucleoside Hydrolases from the Structures of Two Isozymes from Sulfolobus solfataricus.
Biochemistry, 51, 2012
6S81
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BU of 6s81 by Molmil
Crystal structure of methionine adenosyltransferase from Pyrococcus furiosus
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MANGANESE (II) ION, ...
著者Degano, M, Minici, C, Porcelli, M.
登録日2019-07-08
公開日2020-02-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.784 Å)
主引用文献Structures of catalytic cycle intermediates of the Pyrococcus furiosus methionine adenosyltransferase demonstrate negative cooperativity in the archaeal orthologues.
J.Struct.Biol., 210, 2020
6S83
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BU of 6s83 by Molmil
Crystal structure of methionine adenosyltransferase from Pyrococcus furiosus in complex with AMPPCP, SAM, and PCP
分子名称: MAGNESIUM ION, METHYLENEDIPHOSPHONIC ACID, PHOSPHATE ION, ...
著者Degano, M, Minici, C, Porcelli, M.
登録日2019-07-08
公開日2020-02-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.336 Å)
主引用文献Structures of catalytic cycle intermediates of the Pyrococcus furiosus methionine adenosyltransferase demonstrate negative cooperativity in the archaeal orthologues.
J.Struct.Biol., 210, 2020
6ZTD
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BU of 6ztd by Molmil
Crystal structure of the BCR Fab fragment from subset #169 case P6540
分子名称: Heavy chain of the Fab fragment from BCR derived from the P6540 CLL clone, Light chain of the Fab fragment from BCR derived from the P6540 CLL clone
著者Carriles, A.A, Minici, C, Degano, M.
登録日2020-07-18
公開日2021-05-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.43 Å)
主引用文献Higher-order immunoglobulin repertoire restrictions in CLL: the illustrative case of stereotyped subsets 2 and 169.
Blood, 137, 2021
3FZ0
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BU of 3fz0 by Molmil
Inosine-Guanosine Nucleoside Hydrolase (IG-NH)
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Nucleoside hydrolase, ...
著者Vandemeulebroucke, A, Minici, C, Bruno, I, Muzzolini, L, Tornaghi, P, Parkin, D.W, Schramm, V.L, Versees, W, Steyaert, J, Degano, M.
登録日2009-01-23
公開日2010-01-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and mechanism of the 6-oxopurine nucleosidase from Trypanosoma brucei brucei
Biochemistry, 49, 2010
6O1Q
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BU of 6o1q by Molmil
The N-terminal domain of NPHP1 folds into an antiparallel three-stranded coiled coil
分子名称: Nephrocystin-1
著者Musco, G, Mannella, V.
登録日2019-02-21
公開日2019-08-14
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献The N-Terminal Domain of NPHP1 Folds into a Monomeric Left-Handed Antiparallel Three-Stranded Coiled Coil with Anti-apoptotic Function.
Acs Chem.Biol., 14, 2019
8RIH
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BU of 8rih by Molmil
Crystal structure of the Saccharomyces cerevisiae URH1p riboside hydrolase
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Uridine ribohydrolase
著者Degano, M, Carriles, A.A.
登録日2023-12-18
公開日2024-07-03
最終更新日2024-07-24
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Structure-Function Insights into the Dual Role in Nucleobase and Nicotinamide Metabolism and a Possible Use in Cancer Gene Therapy of the URH1p Riboside Hydrolase.
Int J Mol Sci, 25, 2024
3B9X
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BU of 3b9x by Molmil
Crystal structure of the E. coli pyrimidine nucleoside hydrolase YeiK in complex with inosine
分子名称: CALCIUM ION, INOSINE, Pyrimidine-specific ribonucleoside hydrolase rihB, ...
著者Iovane, E, Degano, M.
登録日2007-11-07
公開日2008-04-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for substrate specificity in group I nucleoside hydrolases
Biochemistry, 47, 2008
4I71
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BU of 4i71 by Molmil
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with a trypanocidal compound
分子名称: (2R,3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidine-3,4-diol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ...
著者Giannese, F, Degano, M.
登録日2012-11-30
公開日2013-08-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor
Acta Crystallogr.,Sect.D, 69, 2013
4I73
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BU of 4i73 by Molmil
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with compound UAMC-00312
分子名称: (2R,3R,4S)-2-(hydroxymethyl)-1-[(4-hydroxythieno[3,2-d]pyrimidin-7-yl)methyl]pyrrolidine-3,4-diol, CALCIUM ION, Inosine-adenosine-guanosine-nucleoside hydrolase, ...
著者Giannese, F, Degano, M.
登録日2012-11-30
公開日2013-08-07
最終更新日2013-12-18
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor
Acta Crystallogr.,Sect.D, 69, 2013
4I72
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BU of 4i72 by Molmil
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with Immucillin A
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,4-PYRROLIDINEDIOL,2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-2S,3S,4R,5R, CALCIUM ION, ...
著者Giannese, F, Degano, M.
登録日2012-11-30
公開日2013-08-07
最終更新日2013-12-18
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor
Acta Crystallogr.,Sect.D, 69, 2013
4I75
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BU of 4i75 by Molmil
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with the NiTris metalorganic complex
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Inosine-adenosine-guanosine-nucleoside hydrolase, ...
著者Giannese, F, Degano, M.
登録日2012-11-30
公開日2013-08-07
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor
Acta Crystallogr.,Sect.D, 69, 2013
4I70
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BU of 4i70 by Molmil
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase
分子名称: CALCIUM ION, Inosine-adenosine-guanosine-nucleoside hydrolase
著者Giannese, F, Degano, M.
登録日2012-11-30
公開日2013-08-07
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor
Acta Crystallogr.,Sect.D, 69, 2013
4I74
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BU of 4i74 by Molmil
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with compound UAMC-00312 and allosterically inhibited by a Ni2+ ion
分子名称: (2R,3R,4S)-2-(hydroxymethyl)-1-[(4-hydroxythieno[3,2-d]pyrimidin-7-yl)methyl]pyrrolidine-3,4-diol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ...
著者Giannese, F, Degano, M.
登録日2012-11-30
公開日2013-08-07
最終更新日2013-12-18
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor
Acta Crystallogr.,Sect.D, 69, 2013

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