5FRO
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![BU of 5fro by Molmil](/molmil-images/mine/5fro) | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ446 (compound 4f) | 分子名称: | 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-[2-(phenylsulfonyl)ethyl]-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ... | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | 登録日 | 2015-12-18 | 公開日 | 2016-02-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases. Acs Chem.Biol., 11, 2016
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5FRN
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![BU of 5frn by Molmil](/molmil-images/mine/5frn) | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ419 (compound 4c) | 分子名称: | 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-(5-oxidanylpentyl)-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ... | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | 登録日 | 2015-12-18 | 公開日 | 2016-02-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases. Acs Chem.Biol., 11, 2016
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5FRM
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![BU of 5frm by Molmil](/molmil-images/mine/5frm) | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ384 (compound 4a) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-azanylidene-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', ... | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | 登録日 | 2015-12-18 | 公開日 | 2016-02-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases. Acs Chem.Biol., 11, 2016
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5MMB
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![BU of 5mmb by Molmil](/molmil-images/mine/5mmb) | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ434 (compound 6p) | 分子名称: | DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), GLYCEROL, ... | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | 登録日 | 2016-12-09 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors. J. Med. Chem., 60, 2017
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5MMA
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![BU of 5mma by Molmil](/molmil-images/mine/5mma) | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ379 (compound 5'g) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | 登録日 | 2016-12-09 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors. J. Med. Chem., 60, 2017
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6RNY
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![BU of 6rny by Molmil](/molmil-images/mine/6rny) | PFV intasome - nucleosome strand transfer complex | 分子名称: | DNA (108-MER), DNA (128-MER), DNA (33-MER), ... | 著者 | Pye, V.E, Renault, L, Maskell, D.P, Cherepanov, P, Costa, A. | 登録日 | 2019-05-09 | 公開日 | 2019-09-25 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer. Nat Commun, 10, 2019
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8CBW
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![BU of 8cbw by Molmil](/molmil-images/mine/8cbw) | CryoEM structure of the Hendra henipavirus nucleocapsid sauronoid assembly monomer | 分子名称: | Nucleocapsid, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3') | 著者 | Passchier, T.C, Maskell, D.P, Edwards, T.A, Barr, J.N. | 登録日 | 2023-01-26 | 公開日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.485 Å) | 主引用文献 | The cryoEM structure of the Hendra henipavirus nucleoprotein reveals insights into paramyxoviral nucleocapsid architectures. Sci Rep, 14, 2024
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8C4H
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![BU of 8c4h by Molmil](/molmil-images/mine/8c4h) | CryoEM structure of the Hendra henipavirus nucleocapsid sauronoid assembly multimer | 分子名称: | Nucleocapsid, RNA (84-MER) | 著者 | Passchier, T.C, Maskell, D.P, Edwards, T.A, Barr, J.N. | 登録日 | 2023-01-04 | 公開日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.485 Å) | 主引用文献 | The cryoEM structure of the Hendra henipavirus nucleoprotein reveals insights into paramyxoviral nucleocapsid architectures. Sci Rep, 14, 2024
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6YRF
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![BU of 6yrf by Molmil](/molmil-images/mine/6yrf) | Vip3Bc1 tetramer | 分子名称: | Vegetative insecticidal protein | 著者 | Thompson, R.F, Byrne, M.J, Iadanza, M.I, Arribas Perez, M, Maskell, D.P, George, R.M, Hesketh, E.L, Beales, P.A, Zack, M.D, Berry, C. | 登録日 | 2020-04-20 | 公開日 | 2021-03-17 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane. Nat Commun, 12, 2021
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5MLU
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![BU of 5mlu by Molmil](/molmil-images/mine/5mlu) | Crystal structure of the PFV GAG CBS bound to a mononucleosome | 分子名称: | DNA (145-MER), Histone H2A type 1, Histone H2B, ... | 著者 | Pye, V.E, Maskell, D.P, Lesbats, P, Cherepanov, P. | 登録日 | 2016-12-07 | 公開日 | 2017-05-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for spumavirus GAG tethering to chromatin. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5LLJ
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![BU of 5llj by Molmil](/molmil-images/mine/5llj) | |
7ZPP
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![BU of 7zpp by Molmil](/molmil-images/mine/7zpp) | Cryo-EM structure of the MVV CSC intasome at 4.5A resolution | 分子名称: | Integrase, vDNA, non-transferred strand, ... | 著者 | Ballandras-Colas, A, Maskell, D, Pye, V.E, Locke, J, Swuec, S, Kotecha, A, Costa, A, Cherepanov, P. | 登録日 | 2022-04-28 | 公開日 | 2022-05-11 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | A supramolecular assembly mediates lentiviral DNA integration Science, 355, 2017
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5M0R
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![BU of 5m0r by Molmil](/molmil-images/mine/5m0r) | Cryo-EM reconstruction of the maedi-visna virus (MVV) strand transfer complex | 分子名称: | integrase, tDNA, vDNA, ... | 著者 | Pye, V.E, Ballandras-Colas, A, Maskell, D, Locke, J, Kotecha, A, Costa, A, Cherepanov, P. | 登録日 | 2016-10-05 | 公開日 | 2017-01-18 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | 主引用文献 | A supramolecular assembly mediates lentiviral DNA integration. Science, 355, 2017
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7ZBN
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![BU of 7zbn by Molmil](/molmil-images/mine/7zbn) | |
5T3A
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![BU of 5t3a by Molmil](/molmil-images/mine/5t3a) | |
7NTX
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![BU of 7ntx by Molmil](/molmil-images/mine/7ntx) | |
6R0C
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![BU of 6r0c by Molmil](/molmil-images/mine/6r0c) | Human-D02 Nucleosome Core Particle with biotin-streptavidin label | 分子名称: | DNA (142-MER), Histone H2A type 1, Histone H2B type 1-C/E/F/G/I, ... | 著者 | Pye, V.E, Wilson, M.D, Cherepanov, P, Costa, A. | 登録日 | 2019-03-12 | 公開日 | 2019-09-25 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer. Nat Commun, 10, 2019
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6YRG
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![BU of 6yrg by Molmil](/molmil-images/mine/6yrg) | |
7ABL
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![BU of 7abl by Molmil](/molmil-images/mine/7abl) | HBV pgRNA T=4 NCP icosahedral symmetry | 分子名称: | Capsid protein | 著者 | Patel, N, Clark, S, Weis, E.U, Mata, C.P, Bohon, J, Farquhar, E, Ranson, N.A, Twarock, R, Stockley, P.G. | 登録日 | 2020-09-07 | 公開日 | 2021-10-27 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | In vitro functional analysis of gRNA sites regulating assembly of hepatitis B virus. Commun Biol, 4, 2021
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5NO1
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![BU of 5no1 by Molmil](/molmil-images/mine/5no1) | |