5MMB
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ434 (compound 6p)
Summary for 5MMB
Entry DOI | 10.2210/pdb5mmb/pdb |
Descriptor | PFV INTEGRASE, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... (10 entities in total) |
Functional Keywords | hiv, pfv, prototype foamy virus, integrase, strand transfer, insti, tetramer, intasome, integration, inhibitor, drug, viral protein |
Biological source | Human spumaretrovirus (SFVcpz(hu)) More |
Total number of polymer chains | 4 |
Total formula weight | 102378.03 |
Authors | Maskell, D.P.,Pye, V.E.,Cherepanov, P. (deposition date: 2016-12-09, release date: 2017-08-02, Last modification date: 2024-01-17) |
Primary citation | Zhao, X.Z.,Smith, S.J.,Maskell, D.P.,Metifiot, M.,Pye, V.E.,Fesen, K.,Marchand, C.,Pommier, Y.,Cherepanov, P.,Hughes, S.H.,Burke, T.R. Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors. J. Med. Chem., 60:7315-7332, 2017 Cited by PubMed: 28737946DOI: 10.1021/acs.jmedchem.7b00596 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.77 Å) |
Structure validation
Download full validation report