5MMB
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ434 (compound 6p)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | PFV INTEGRASE | polymer | 395 | 44456.7 | 2 | UniProt (P14350) Pfam (PF17921) Pfam (PF00665) Pfam (PF18103) In PDB | Human spumaretrovirus (SFVcpz(hu)) | Pr125Pol |
| 2 | C | DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3') | polymer | 19 | 5834.8 | 1 | synthetic construct | ||
| 3 | D | DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3') | polymer | 17 | 5195.4 | 1 | synthetic construct | ||
| 4 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 6 | A, B | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 7 | C, A, B | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 8 | A | methyl 3-[5-azanyl-6-[[2,4-bis(fluoranyl)phenyl]methylcarbamoyl]-8-oxidanyl-7-oxidanylidene-1,8-naphthyridin-3-yl]propanoate | non-polymer | 432.4 | 1 | Chemie (OUY) | |||
| 9 | B, A | HEXANE-1,6-DIOL | non-polymer | 118.2 | 3 | Chemie (HEZ) | |||
| 10 | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 392 (UniProt: P14350)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Cys 1 | - | expression tag |
| Ser 217 | Gly 968 | variant |
| Gly 218 | Ser 969 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 99943.6 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 2434.4 | |
| All* | Total formula weight | 102378.0 |
