5MMB

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ434 (compound 6p)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0015074	biological_process	DNA integration
B	0003676	molecular_function	nucleic acid binding
B	0015074	biological_process	DNA integration

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	HIS62
A	HIS66
A	CYS96
A	CYS99

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 402

Chain	Residue
A	ASP128
A	ASP185
A	OUY417
A	HOH524
D	HOH109

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 403

Chain	Residue
A	ASP128
A	GLU221
A	ASN224
A	OUY417
D	HOH103

---

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 404

Chain	Residue
A	SER136
A	GLN137
A	LYS241

---

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 A 405

Chain	Residue
A	ALA188
A	OUY417

---

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 A 406

Chain	Residue
A	LYS228
A	SER332
A	LEU333
A	ARG336
A	HOH501
A	HOH502

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 A 407

Chain	Residue
A	HIS338
A	LYS339
A	HIS357

---

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 A 408

Chain	Residue
A	LYS159
A	ALA165

---

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 A 409

Chain	Residue
A	GLN60
A	TYR80
A	PHE278
A	HOH532

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 A 410

Chain	Residue
A	ASN171
A	THR174
A	ARG202
B	PRO247

---

site_id	AD2
Number of Residues	5
Details	binding site for residue SO4 A 411

Chain	Residue
A	ARG114
A	TYR303
A	PRO305
C	DC6
C	GOL101

---

site_id	AD3
Number of Residues	3
Details	binding site for residue GOL A 412

Chain	Residue
A	SER162
A	THR163
A	SER164

---

site_id	AD4
Number of Residues	2
Details	binding site for residue GOL A 413

Chain	Residue
A	ASP116
C	DT3

---

site_id	AD5
Number of Residues	4
Details	binding site for residue GOL A 414

Chain	Residue
A	HIS19
A	TYR20
B	THR210
B	HIS213

---

site_id	AD6
Number of Residues	5
Details	binding site for residue GOL A 415

Chain	Residue
A	SER225
A	THR232
A	ARG334
A	HOH522
D	DC16

---

site_id	AD7
Number of Residues	5
Details	binding site for residue GOL A 416

Chain	Residue
A	LEU292
A	GLN296
B	TYR263
B	GLY271
B	ASP273

---

site_id	AD8
Number of Residues	17
Details	binding site for residue OUY A 417

Chain	Residue
A	ASP128
A	ASP185
A	GLN186
A	TYR212
A	PRO214
A	GLN215
A	GLU221
A	ARG329
A	MG402
A	MG403
A	SO4405
A	HOH503
A	HOH508
C	DG4
D	DC16
D	DA17
D	HOH109

---

site_id	AD9
Number of Residues	5
Details	binding site for residue HEZ A 418

Chain	Residue
A	TRP315
A	THR372
A	HIS374
A	GLN375
C	DG10

---

site_id	AE1
Number of Residues	6
Details	binding site for residue HEZ A 419

Chain	Residue
A	TYR257
A	LYS262
A	GLN267
A	GLY271
A	ASN280
A	ILE298

---

site_id	AE2
Number of Residues	3
Details	binding site for residue MG B 401

Chain	Residue
B	ASP128
B	ASP185
C	DA19

---

site_id	AE3
Number of Residues	5
Details	binding site for residue SO4 B 402

Chain	Residue
B	LYS219
B	ARG222
B	SER258
B	PRO259
B	VAL260

---

site_id	AE4
Number of Residues	1
Details	binding site for residue GOL B 403

Chain	Residue
B	GLY218

---

site_id	AE5
Number of Residues	5
Details	binding site for residue HEZ B 404

Chain	Residue
A	SER175
B	LEU155
B	TYR156
B	TYR243
B	GLN250

---

site_id	AE6
Number of Residues	6
Details	binding site for residue GOL C 101

Chain	Residue
A	VAL260
A	SO4411
C	DC6
C	DA7
C	DT8
D	DC11

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	312
Details	Domain: {"description":"Integrase catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00457","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---