5FRN

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ419 (compound 4c)

Summary for 5FRN

• Entry DOI: 10.2210/pdb5frn/pdb
• Related: 5FRM 5FRO
• Descriptor: Integrase, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ... (9 entities in total)
• Functional Keywords: recombination, viral protein/dna, protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna- binding, zinc binding, hhcc motif, viral protein, inhibitor, dna-binding protein-dna complex
• Biological source: Human spumaretrovirus (SFVcpz(hu)); More
• Total number of polymer chains: 4
• Total formula weight: 101522.90

Authors

Maskell, D.P.,Pye, V.E.,Cherepanov, P. (deposition date: 2015-12-18, release date: 2016-02-17, Last modification date: 2024-01-10)

• Primary citation: Zhao, X.Z.,Smith, S.J.,Maskell, D.P.,Metifiot, M.,Pye, V.E.,Fesen, K.,Marchand, C.,Pommier, Y.,Cherepanov, P.,Hughes, S.H.,Burke, T.R.J.; HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.; Acs Chem.Biol., 11:1074-, 2016; PubMed: 26808478; DOI: 10.1021/ACSCHEMBIO.5B00948

Experimental method

X-RAY DIFFRACTION (2.85 Å)