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5FRN

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ419 (compound 4c)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BIntegrasepolymer39544456.72UniProt (P14350)
Pfam (PF17921)
Pfam (PF00665)
Pfam (PF18103)
In PDB
Human spumaretrovirus (SFVcpz(hu))Pr125Pol
2C5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3'polymer195834.81SYNTHETIC CONSTRUCT
3D5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3'polymer175195.41SYNTHETIC CONSTRUCT
4AZINC IONnon-polymer65.41Chemie (ZN)
5AMAGNESIUM IONnon-polymer24.32Chemie (MG)
6A, B, CGLYCEROLnon-polymer92.16Chemie (GOL)
7A, BSULFATE IONnon-polymer96.15Chemie (SO4)
8D4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-(5-oxidanylpentyl)-1,8-naphthyridine-3-carboxamidenon-polymer432.41Chemie (QUW)
9waterwater18.091Chemie (HOH)
Sequence modifications
A, B: 3 - 392 (UniProt: P14350)
PDBExternal DatabaseDetails
Gly -2-expression tag
Pro -1-expression tag
Gly 0-expression tag
Cys 1-expression tag
Asn 2-expression tag
Ser 217Gly 968variant
Gly 218Ser 969variant
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight99943.6
Non-Polymers*Number of molecules15
Total formula weight1579.3
All*Total formula weight101522.9
*Water molecules are not included.

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PDB entries from 2024-07-17

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