4WT2
| Co-crystal Structure of MDM2 in Complex with AM-7209 | 分子名称: | 4-({[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl}amino)-2-methoxybenzoic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | 登録日 | 2014-10-30 | 公開日 | 2014-12-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2-p53 Interaction. J.Med.Chem., 57, 2014
|
|
4OGV
| Co-Crystal Structure of MDM2 with Inhibitor Compound 49 | 分子名称: | E3 ubiquitin-protein ligase Mdm2, [(2S,5R,6R)-4-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid | 著者 | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | 登録日 | 2014-01-16 | 公開日 | 2014-04-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.197 Å) | 主引用文献 | Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
|
|
4OGN
| Co-Crystal Structure of MDM2 with Inhbitor Compound 3 | 分子名称: | 6-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | 登録日 | 2014-01-16 | 公開日 | 2014-04-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.377 Å) | 主引用文献 | Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
|
|
4OGT
| Co-Crystal Structure of MDM2 with Inhbitor Compound 46 | 分子名称: | 6-{[(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | 登録日 | 2014-01-16 | 公開日 | 2014-04-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.5361 Å) | 主引用文献 | Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
|
|
4OBA
| Co-crystal structure of MDM2 with Inhibitor Compound 4 | 分子名称: | E3 ubiquitin-protein ligase Mdm2, [(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid | 著者 | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | 登録日 | 2014-01-07 | 公開日 | 2014-03-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | 主引用文献 | Selective and Potent Morpholinone Inhibitors of the MDM2-p53 Protein-Protein Interaction. J.Med.Chem., 57, 2014
|
|
4OCC
| co-crystal structure of MDM2(17-111) in complex with compound 48 | 分子名称: | E3 ubiquitin-protein ligase Mdm2, [(2R,5R,6R)-4-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid | 著者 | Huang, X. | 登録日 | 2014-01-08 | 公開日 | 2014-04-02 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
|
|
4ODE
| Co-Crystal Structure of MDM2 with Inhibitor Compound 4 | 分子名称: | (2-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}-1,3-thiazol-5-yl)acetic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | 登録日 | 2014-01-10 | 公開日 | 2014-04-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
|
|
4ODF
| Co-Crystal Structure of MDM2 with Inhibitor Compound 47 | 分子名称: | 6-{[(2S,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2 | 著者 | Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M. | 登録日 | 2014-01-10 | 公開日 | 2014-04-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.2006 Å) | 主引用文献 | Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J.Med.Chem., 57, 2014
|
|
7N8L
| |
7N8E
| |
7N8M
| |
8GKF
| |
5XUR
| Crystal Structure of Rv2466c C22S Mutant | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Thioredoxin-like reductase Rv2466c | 著者 | Zhang, X, Li, H. | 登録日 | 2017-06-25 | 公開日 | 2018-03-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.996 Å) | 主引用文献 | Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis. ACS Infect Dis, 4, 2018
|
|
8PKW
| Kelch domain of KEAP1 in complex with a ortho-dimethylbenzene linked cyclic peptide 5 (ortho-WRCDPETaEC). | 分子名称: | (2-methylphenyl)methanol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Braun, M.B, Bischof, L, Hartmann, M.D. | 登録日 | 2023-06-27 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders. J.Chem.Inf.Model., 63, 2023
|
|
8PKX
| Kelch domain of KEAP1 in complex with a ortho-dimethylbenzene linked cyclic peptide 11 (ortho-WRCNPETaEC). | 分子名称: | (2-methylphenyl)methanol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Braun, M.B, Bischof, L, Hartmann, M.D. | 登録日 | 2023-06-27 | 公開日 | 2023-11-15 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders. J.Chem.Inf.Model., 63, 2023
|
|
8PKU
| Kelch domain of KEAP1 in complex with ortho-dimethylbenzene linked cyclic peptide 3 (ortho-WRCDEETGEC). | 分子名称: | (2-methylphenyl)methanol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Braun, M.B, Bischof, L, Hartmann, M.D. | 登録日 | 2023-06-27 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders. J.Chem.Inf.Model., 63, 2023
|
|
8PKV
| Kelch domain of KEAP1 in complex with a ortho-dimethylbenzene linked cyclic peptide 4 (ortho-WRCDEETGEC). | 分子名称: | (2-methylphenyl)methanol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Braun, M.B, Bischof, L, Hartmann, M.D. | 登録日 | 2023-06-27 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders. J.Chem.Inf.Model., 63, 2023
|
|
6JZE
| Crystal structure of VASH2-SVBP complex with the magic triangle I3C | 分子名称: | 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 2 | 著者 | Chen, Z, Ling, Y, Zeyuan, G, Zhu, L. | 登録日 | 2019-05-01 | 公開日 | 2019-08-07 | 最終更新日 | 2023-04-05 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer. Nat Commun, 10, 2019
|
|
6JZD
| Crystal structure of peptide-bound VASH2-SVBP complex | 分子名称: | GLU-GLY-GLU-GLU-TYR, Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 2 | 著者 | Chen, Z, Ling, Y, Zeyuan, G, Zhu, L. | 登録日 | 2019-05-01 | 公開日 | 2019-07-17 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.479 Å) | 主引用文献 | Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer. Nat Commun, 10, 2019
|
|
6JZC
| Structural basis of tubulin detyrosination | 分子名称: | GLYCEROL, Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 2 | 著者 | Chen, Z, Ling, Y, Zeyuan, G, Zhu, L. | 登録日 | 2019-05-01 | 公開日 | 2019-07-17 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | 主引用文献 | Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer. Nat Commun, 10, 2019
|
|