7N8L

PptT PAP(CoA) 9016 complex

Summary for 7N8L

Entry DOI	10.2210/pdb7n8l/pdb
Descriptor	4'-phosphopantetheinyl transferase PptT, COENZYME A, N-(2,6-diethylphenyl)-N'-(N-propylcarbamimidoyl)urea, ... (7 entities in total)
Functional Keywords	inhibitor, structural genomics, psi-biology, protein structure initiative, tb structural genomics consortium, tbsgc, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	2
Total formula weight	55948.58
Authors	Mosior, J.W.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2021-06-15, release date: 2022-02-02, Last modification date: 2023-10-18)
Primary citation	Ottavi, S.,Scarry, S.M.,Mosior, J.,Ling, Y.,Roberts, J.,Singh, A.,Zhang, D.,Goullieux, L.,Roubert, C.,Bacque, E.,Lagiakos, H.R.,Vendome, J.,Moraca, F.,Li, K.,Perkowski, A.J.,Ramesh, R.,Bowler, M.M.,Tracy, W.,Feher, V.A.,Sacchettini, J.C.,Gold, B.S.,Nathan, C.F.,Aube, J. In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas. J.Med.Chem., 65:1996-2022, 2022 Cited by PubMed: 35044775 DOI: 10.1021/acs.jmedchem.1c01565 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation