7TRJ
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![BU of 7trj by Molmil](/molmil-images/mine/7trj) | The eukaryotic translation initiation factor 2B from Homo sapiens with a H160D mutation in the beta subunit | 分子名称: | Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ... | 著者 | Wang, L, Schoof, M, Lawrence, R, Boone, M, Frost, A, Walter, P. | 登録日 | 2022-01-29 | 公開日 | 2022-04-27 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation. Elife, 11, 2022
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7L70
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![BU of 7l70 by Molmil](/molmil-images/mine/7l70) | The eukaryotic translation initiation factor 2B from Homo sapiens in its apo form | 分子名称: | Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ... | 著者 | Wang, L, Schoof, M, Lawrence, R, Boone, M, Frost, A, Walter, P. | 登録日 | 2020-12-24 | 公開日 | 2021-03-24 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | eIF2B conformation and assembly state regulates the integrated stress response. Elife, 10, 2021
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7RLO
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![BU of 7rlo by Molmil](/molmil-images/mine/7rlo) | Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex with a viral protein NSs | 分子名称: | Non-structural protein NS-S, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | 著者 | Wang, L, Schoof, M, Cogan, J, Lawrence, R, Boone, M, Wuerth, J, Frost, M, Walter, P. | 登録日 | 2021-07-26 | 公開日 | 2021-12-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Commun, 12, 2021
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8TQO
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![BU of 8tqo by Molmil](/molmil-images/mine/8tqo) | Eukaryotic translation initiation factor 2B tetramer | 分子名称: | Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, Translation initiation factor eIF-2B subunit epsilon, ... | 著者 | Wang, L, Lawrence, R, Sangwan, S, Anand, A, Shoemaker, S, Deal, A, Marqusee, S, Watler, P. | 登録日 | 2023-08-08 | 公開日 | 2023-12-06 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling. Nat.Chem.Biol., 20, 2024
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8TQZ
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![BU of 8tqz by Molmil](/molmil-images/mine/8tqz) | Eukaryotic translation initiation factor 2B with a mutation (L516A) in the delta subunit | 分子名称: | Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ... | 著者 | Wang, L, Lawrence, R, Sangwan, S, Anand, A, Shoemaker, S, Deal, A, Marqusee, S, Watler, P. | 登録日 | 2023-08-08 | 公開日 | 2023-12-06 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling. Nat.Chem.Biol., 20, 2024
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6B9X
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![BU of 6b9x by Molmil](/molmil-images/mine/6b9x) | Crystal structure of Ragulator | 分子名称: | Hepatitis B virus x interacting protein, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... | 著者 | SU, M.-Y, Hurley, J.H. | 登録日 | 2017-10-11 | 公開日 | 2017-11-08 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex. Mol. Cell, 68, 2017
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7L7G
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![BU of 7l7g by Molmil](/molmil-images/mine/7l7g) | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens (updated model of PDB ID: 6CAJ) | 分子名称: | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | 著者 | Tsai, J.C, Miller-Vedam, L.E, Anand, A, Jaishankar, P, Nguyen, H.C, Wang, L, Renslo, A.R, Frost, A, Walter, P. | 登録日 | 2020-12-28 | 公開日 | 2021-03-24 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | eIF2B conformation and assembly state regulates the integrated stress response. Elife, 10, 2021
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3SW2
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![BU of 3sw2 by Molmil](/molmil-images/mine/3sw2) | X-ray crystal structure of human FXA in complex with 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide | 分子名称: | 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide, CALCIUM ION, Coagulation factor X, ... | 著者 | Klei, H.E. | 登録日 | 2011-07-13 | 公開日 | 2011-11-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
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