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3IH7
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BU of 3ih7 by Molmil
Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA
分子名称: 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', 5'-D(AP*TP*CP*TP*GP*GP*AP*CP*CP*TP*GP*CP*A)-3', N-glycosylase/DNA lyase
著者Verdine, G.L, Crenshaw, C.M, Oo, K.S, Kutchukian, P.S.
登録日2009-07-29
公開日2010-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A Catalytic Checkpoint in Base Excision by the Human 8-Oxoguanine DNA Glycosylase hOGG1
To be Published
3V3B
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BU of 3v3b by Molmil
Structure of the Stapled p53 Peptide Bound to Mdm2
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, SAH-p53-8 stapled-peptide
著者Baek, S, Kutchukian, P.S, Verdine, G.L, Huber, R, Holak, T.A, Ki Won, L, Popowicz, G.M.
登録日2011-12-13
公開日2012-01-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the stapled p53 peptide bound to Mdm2.
J.Am.Chem.Soc., 134, 2012
4MTA
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BU of 4mta by Molmil
Crystal structure of Pim-1 kinase domain in complex with 2-methyl-5-phenylfuran-3-carboxylic acid
分子名称: 2-methyl-5-phenylfuran-3-carboxylic acid, GLYCEROL, Serine/threonine-protein kinase pim-1
著者Scheufler, C, Be, C.
登録日2013-09-19
公開日2015-01-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Large scale meta-analysis of fragment-based screening campaigns: privileged fragments and complementary technologies.
J Biomol Screen, 20, 2015
4C3F
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BU of 4c3f by Molmil
Structure of Lck in complex with a compound discovered by Virtual Fragment Linking
分子名称: N-phenyl-4-(5-phenyl-1H-pyrazol-4-yl)pyrimidin-2-amine, TYROSINE-PROTEIN KINASE LCK
著者Cowan-Jacob, S.W, Rummel, G, Stark, W.
登録日2013-08-23
公開日2013-10-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Efficient search of chemical space: navigating from fragments to structurally diverse chemotypes.
J. Med. Chem., 56, 2013
7RNI
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BU of 7rni by Molmil
Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen
分子名称: ACETYL GROUP, DIMETHYLALLYL DIPHOSPHATE, MAGNESIUM ION, ...
著者Hruza, A, Strickland, C.L.
登録日2021-07-29
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.978 Å)
主引用文献Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.
ACS Med Chem Lett, 12, 2021
7RN5
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BU of 7rn5 by Molmil
Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen
分子名称: ACETYL GROUP, MAGNESIUM ION, PYROPHOSPHATE, ...
著者Hruza, A, Strickland, C.L.
登録日2021-07-29
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.
ACS Med Chem Lett, 12, 2021
3KTU
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BU of 3ktu by Molmil
Structure of human 8-oxoGuanine Glycosylase 1 bound to fluorninated oxoG-containing DNA
分子名称: CALCIUM ION, DNA (5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*AP*(FDG)P*GP*TP*CP*TP*AP*C)-3'), ...
著者Verdine, G.L, Lee, S.M.
登録日2009-11-26
公開日2010-07-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural investigation of hOGG1 bound to a fluorinated oxoG analog
to be published

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件を2024-06-26に公開中

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