4C3F

Structure of Lck in complex with a compound discovered by Virtual Fragment Linking

Summary for 4C3F

Entry DOI	10.2210/pdb4c3f/pdb
Descriptor	TYROSINE-PROTEIN KINASE LCK, N-phenyl-4-(5-phenyl-1H-pyrazol-4-yl)pyrimidin-2-amine (3 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	30969.51
Authors	Cowan-Jacob, S.W.,Rummel, G.,Stark, W. (deposition date: 2013-08-23, release date: 2013-10-23, Last modification date: 2023-12-20)
Primary citation	Wassermann, A.M.,Kutchukian, P.S.,Lounkine, E.,Luethi, T.,Hamon, J.,Bocker, M.T.,Malik, H.A.,Cowan-Jacob, S.W.,Glick, M. Efficient search of chemical space: navigating from fragments to structurally diverse chemotypes. J. Med. Chem., 56:8879-8891, 2013 Cited by PubMed: 24117015 DOI: 10.1021/jm401309q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation