4C3F
Structure of Lck in complex with a compound discovered by Virtual Fragment Linking
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TYROSINE-PROTEIN KINASE LCK | polymer | 267 | 30656.2 | 1 | UniProt (P06239) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | LEUKOCYTE C-TERMINAL SRC KINASE, LSK, LYMPHOCYTE CELL-SPECIFIC PROTEIN-TYROSINE KINASE, PROTEIN YT16, PROTO-ONCOGENE LCK, T CELL-SPECIFIC PROTEIN-TYROSINE KINASE, P56-LCK |
| 2 | B (A) | N-phenyl-4-(5-phenyl-1H-pyrazol-4-yl)pyrimidin-2-amine | non-polymer | 313.4 | 1 | Chemie (7KW) | |||
| 3 | C (A) | water | water | 18.0 | 355 | Chemie (HOH) |
Sequence modifications
A: 237 - 501 (UniProt: P06239)
| PDB | External Database | Details |
|---|---|---|
| Gly 235 | - | expression tag |
| Pro 236 | - | expression tag |
| Asn 364 | Asp 364 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30656.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 313.4 | |
| All* | Total formula weight | 30969.5 |
