7RN5

Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen

Summary for 7RN5

Entry DOI	10.2210/pdb7rn5/pdb
Descriptor	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, ACETYL GROUP, ... (8 entities in total)
Functional Keywords	protein inhibitor complex, transferase-transferase inhibitor complex, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	2
Total formula weight	93586.73
Authors	Hruza, A.,Strickland, C.L. (deposition date: 2021-07-29, release date: 2021-09-08, Last modification date: 2023-10-18)
Primary citation	Bukhtiyarova, M.,Cook, E.M.,Hancock, P.J.,Hruza, A.W.,Shaw, A.W.,Adam, G.C.,Barnard, R.J.O.,McKenna, P.M.,Holloway, M.K.,Bell, I.M.,Carroll, S.,Cornella-Taracido, I.,Cox, C.D.,Kutchukian, P.S.,Powell, D.A.,Strickland, C.,Trotter, B.W.,Tudor, M.,Wolkenberg, S.,Li, J.,Tellers, D.M. Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen. ACS Med Chem Lett, 12:99-106, 2021 Cited by PubMed: 33488970 DOI: 10.1021/acsmedchemlett.0c00551 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation