7RN5
Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | polymer | 377 | 44086.1 | 1 | UniProt (Q04631) Pfam (PF01239) | Rattus norvegicus (Rat) | CAAX farnesyltransferase subunit alpha,FTase-alpha,Ras proteins prenyltransferase subunit alpha,Type I protein geranyl-geranyltransferase subunit alpha,GGTase-I-alpha |
| 2 | B (B) | Protein farnesyltransferase subunit beta | polymer | 437 | 48722.3 | 1 | UniProt (Q02293) Pfam (PF00432) | Rattus norvegicus (Rat) | FTase-beta,CAAX farnesyltransferase subunit beta,Ras proteins prenyltransferase subunit beta |
| 3 | C, D (A) | ACETYL GROUP | non-polymer | 44.1 | 2 | Chemie (ACE) | |||
| 4 | E (B) | [4-[[3-(2,2-dimethylpropyl)-1~{H}-benzimidazol-2-yl]methyl]piperazin-1-yl]-(1,3,5-trimethylpyrazol-4-yl)methanone | non-polymer | 422.6 | 1 | Chemie (60I) | |||
| 5 | F (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | G (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | H (B) | PYROPHOSPHATE | non-polymer | 178.0 | 1 | Chemie (PPV) | |||
| 8 | I, J (A, B) | water | water | 18.0 | 290 | Chemie (HOH) |
Sequence modifications
A: 1 - 377 (UniProt: Q04631)
| PDB | External Database | Details |
|---|---|---|
| Thr 156 | Ile 156 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 92808.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 778.4 | |
| All* | Total formula weight | 93586.7 |
