3IH7

Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA

Summary for 3IH7

• Entry DOI: 10.2210/pdb3ih7/pdb
• Related: 1EBM 1N3C 1YQK 1YQR 2I5W 2NOL
• Descriptor: N-glycosylase/DNA lyase, 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', 5'-D(AP*TP*CP*TP*GP*GP*AP*CP*CP*TP*GP*CP*A)-3' (3 entities in total)
• Functional Keywords: disulfide crosslink, dna glycosylase, undamaged dna, (hydrolase, lyase)-dna complex, dna damage, dna repair, glycosidase, hydrolase, lyase, mitochondrion, multifunctional enzyme, nucleus, lyase)/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 43948.81

Authors

Verdine, G.L.,Crenshaw, C.M.,Oo, K.S.,Kutchukian, P.S. (deposition date: 2009-07-29, release date: 2010-11-03, Last modification date: 2023-09-06)

• Primary citation: Crenshaw, C.M.,Oo, K.S.,Kutchukian, P.S.,Verdine, G.L.; A Catalytic Checkpoint in Base Excision by the Human 8-Oxoguanine DNA Glycosylase hOGG1; To be Published,

Experimental method

X-RAY DIFFRACTION (3.1 Å)