3IH7
Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | N-glycosylase/DNA lyase | polymer | 316 | 35651.4 | 1 | UniProt (O15527) Pfam (PF07934) Pfam (PF00730) | Homo sapiens (human) | 8-oxoguanine DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase, AP lyase |
| 2 | B (B) | 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3' | polymer | 14 | 4345.8 | 1 | |||
| 3 | C (C) | 5'-D(AP*TP*CP*TP*GP*GP*AP*CP*CP*TP*GP*CP*A)-3' | polymer | 13 | 3951.6 | 1 |
Sequence modifications
A: 12 - 325 (UniProt: O15527)
| PDB | External Database | Details |
|---|---|---|
| Glu 10 | - | expression tag |
| Phe 11 | - | expression tag |
| Leu 82 | Lys 82 | conflict |
| Cys 292 | Ser 292 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 43948.8 | |
| All* | Total formula weight | 43948.8 |
