7RNI
Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen
Summary for 7RNI
Entry DOI | 10.2210/pdb7rni/pdb |
Descriptor | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, ACETYL GROUP, ... (8 entities in total) |
Functional Keywords | protein inhibitor complex, transferase-transferase inhibitor complex, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 2 |
Total formula weight | 93654.85 |
Authors | Hruza, A.,Strickland, C.L. (deposition date: 2021-07-29, release date: 2021-09-08, Last modification date: 2023-10-18) |
Primary citation | Bukhtiyarova, M.,Cook, E.M.,Hancock, P.J.,Hruza, A.W.,Shaw, A.W.,Adam, G.C.,Barnard, R.J.O.,McKenna, P.M.,Holloway, M.K.,Bell, I.M.,Carroll, S.,Cornella-Taracido, I.,Cox, C.D.,Kutchukian, P.S.,Powell, D.A.,Strickland, C.,Trotter, B.W.,Tudor, M.,Wolkenberg, S.,Li, J.,Tellers, D.M. Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen. ACS Med Chem Lett, 12:99-106, 2021 Cited by PubMed: 33488970DOI: 10.1021/acsmedchemlett.0c00551 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.978 Å) |
Structure validation
Download full validation report