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6MDS
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Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2) with complex biantennary glycan
分子名称: CALCIUM ION, Endo-beta-N-acetylglucosaminidase, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Klontz, E.H, Trastoy, B, Orwenyo, J, Wang, L.X, Guerin, M.E, Sundberg, E.J.
登録日2018-09-05
公開日2019-02-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.
ACS Cent Sci, 5, 2019
6OHE
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Alpha-L-fucosidase AlfC D200A in complex with Fuca(1,6)GlcNAc
分子名称: AlfC, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Klontz, E.H, Sundberg, E.J.
登録日2019-04-05
公開日2020-04-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.14 Å)
主引用文献Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6E58
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Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2)
分子名称: CALCIUM ION, Secreted Endo-beta-N-acetylglucosaminidase (EndoS)
著者Klontz, E.H, Trastoy, B, Gunther, S, Guerin, M.E, Sundberg, E.J.
登録日2018-07-19
公開日2019-02-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.
ACS Cent Sci, 5, 2019
6MDV
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Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2) with high-mannose glycan
分子名称: CALCIUM ION, Endo-beta-N-acetylglucosaminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Klontz, E.H, Trastoy, B, Orwenyo, J, Wang, L.X, Guerin, M.E, Sundberg, E.J.
登録日2018-09-05
公開日2019-02-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.
ACS Cent Sci, 5, 2019
6O1C
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Alpha-L-fucosidase AlfC D200A mutant in complex with 4-nitrophenyl-a-L-fucopyranoside substrate
分子名称: 4-nitrophenyl 6-deoxy-alpha-L-galactopyranoside, AlfC
著者Klontz, E.H, Sundberg, E.J.
登録日2019-02-19
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6O1A
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Alpha-L-fucosidase AlfC from Lactobacillus casei in complex with alpha-L-fucose product
分子名称: AlfC, beta-L-fucopyranose
著者Klontz, E.H, Sundberg, E.J.
登録日2019-02-18
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6O1J
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Alpha-L-fucosidase AlfC fucosyltransferase mutant N243A
分子名称: AlfC, beta-L-fucopyranose
著者Klontz, E.H, Sundberg, E.J.
登録日2019-02-20
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6O18
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Unliganded alpha-L-fucosidase AlfC from Lactobacillus casei
分子名称: AlfC
著者Klontz, E.H, Sundberg, E.J.
登録日2019-02-18
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6O1I
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Alpha-L-fucosidase AlfC fucosyltransferase mutant E274A
分子名称: AlfC
著者Klontz, E.H, Sundberg, E.J.
登録日2019-02-20
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.55 Å)
主引用文献Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6C3U
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Crystal structure of Klebsiella pneumoniae fosfomycin resistance protein (FosAKP) with inhibitor (ANY2) bound
分子名称: 3-bromo-6-(4-nitro-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-2(1H)-one, FosA family fosfomycin resistance glutathione transferase, GLYCEROL, ...
著者Klontz, E.H, Sundberg, E.J.
登録日2018-01-10
公開日2018-12-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens.
Antimicrob. Agents Chemother., 63, 2019
5WEP
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BU of 5wep by Molmil
Crystal structure of fosfomycin resistance protein FosA3 with inhibitor (ANY1) bound
分子名称: 6,6'-(4-nitro-1H-pyrazole-3,5-diyl)bis(3-bromopyrazolo[1,5-a]pyrimidin-2(1H)-one), FosA3, ZINC ION
著者Klontz, E.H, Sundberg, E.J.
登録日2017-07-10
公開日2018-07-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.502 Å)
主引用文献Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens.
Antimicrob. Agents Chemother., 63, 2019
5WEW
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Crystal structure of Klebsiella pneumoniae fosfomycin resistance protein (FosAKP) with inhibitor (ANY1) bound
分子名称: 6,6'-(4-nitro-1H-pyrazole-3,5-diyl)bis(3-bromopyrazolo[1,5-a]pyrimidin-2(1H)-one), Fosfomycin resistance protein, MANGANESE (II) ION
著者Klontz, E.H, Sundberg, E.J.
登録日2017-07-10
公開日2018-07-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.178 Å)
主引用文献Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens.
Antimicrob. Agents Chemother., 63, 2019
6T8K
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Crystal structure of Bacteroides thetaiotamicron EndoBT-3987 in complex with Man9GlcNAc product in P1
分子名称: CALCIUM ION, Endo-beta-N-acetylglucosaminidase F1, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Trastoy, B, Du, J.J, Klontz, E.H, Cifuente, J.O, Sundberg, E.J, Guerin, M.E.
登録日2019-10-24
公開日2020-02-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides.
Nat Commun, 11, 2020
6TCV
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Crystal structure of Bacteroides thetaiotamicron EndoBT-3987 in complex with Man9GlcNAc2Asn substrate
分子名称: ASPARAGINE, Endo-beta-N-acetylglucosaminidase F1, GLYCEROL, ...
著者Trastoy, B, Du, J.J, Klontz, E.H, Cifuente, J.O, Sundberg, E.J, Guerin, M.E.
登録日2019-11-06
公開日2020-02-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.311 Å)
主引用文献Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides.
Nat Commun, 11, 2020
6T8I
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Crystal structure of wild type EndoBT-3987 from Bacteroides thetaiotamicron VPI-5482
分子名称: Endo-beta-N-acetylglucosaminidase F1, GLYCEROL
著者Trastoy, B, Du, J.J, Klontz, E.H, Cifuente, J.O, Sundberg, E.J, Guerin, M.E.
登録日2019-10-24
公開日2020-02-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides.
Nat Commun, 11, 2020
6T8L
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Crystal structure of Bacteroides thetaiotamicron EndoBT-3987 with Man9GlcNAc product in P212121
分子名称: CALCIUM ION, Endo-beta-N-acetylglucosaminidase F1, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Trastoy, B, Du, J.J, Klontz, E.H, Cifuente, J.O, Sundberg, E.J, Guerin, M.E.
登録日2019-10-24
公開日2020-02-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides.
Nat Commun, 11, 2020
6TCW
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Crystal structure of Bacteroides thetaiotamicron EndoBT-3987 with Man5GlcNAc product
分子名称: CALCIUM ION, Endo-beta-N-acetylglucosaminidase F1, GLYCEROL, ...
著者Trastoy, B, Du, J.J, Klontz, E.H, Cifuente, J.O, Sundberg, E.J, Guerin, M.E.
登録日2019-11-06
公開日2020-02-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.599 Å)
主引用文献Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides.
Nat Commun, 11, 2020
8G83
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Structure of NAD+ consuming protein Acinetobacter baumannii TIR domain
分子名称: NAD(+) hydrolase AbTIR
著者Klontz, E.H, Wang, Y, Glendening, G, Carr, J, Tsibouris, T, Buddula, S, Nallar, S, Soares, A, Snyder, G.A.
登録日2023-02-17
公開日2023-10-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献The structure of NAD + consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations.
J.Biol.Chem., 299, 2023
5V91
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Crystal structure of fosfomycin resistance protein from Klebsiella pneumoniae
分子名称: Fosfomycin resistance protein, ZINC ION
著者Klontz, E, Guenther, S, Silverstein, Z, Sundberg, E.
登録日2017-03-22
公開日2017-08-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structure and Dynamics of FosA-Mediated Fosfomycin Resistance in Klebsiella pneumoniae and Escherichia coli.
Antimicrob. Agents Chemother., 61, 2017
5V3D
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Crystal structure of fosfomycin resistance protein from Klebsiella pneumoniae with bound fosfomycin
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, FOSFOMYCIN, ...
著者Klontz, E, Guenther, S, Silverstein, Z, Sundberg, E.
登録日2017-03-07
公開日2017-08-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.539 Å)
主引用文献Structure and Dynamics of FosA-Mediated Fosfomycin Resistance in Klebsiella pneumoniae and Escherichia coli.
Antimicrob. Agents Chemother., 61, 2017
5VB0
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Crystal structure of fosfomycin resistance protein FosA3
分子名称: Fosfomycin resistance protein FosA3, MANGANESE (II) ION, NICKEL (II) ION
著者Klontz, E, Guenther, S, Silverstein, Z, Sundberg, E.
登録日2017-03-28
公開日2017-08-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.689 Å)
主引用文献Structure and Dynamics of FosA-Mediated Fosfomycin Resistance in Klebsiella pneumoniae and Escherichia coli.
Antimicrob. Agents Chemother., 61, 2017
8A64
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cryoEM structure of the catalytically inactive EndoS from S. pyogenes in complex with the Fc region of immunoglobulin G1.
分子名称: Endo-beta-N-acetylglucosaminidase F2, Immunoglobulin gamma-1 heavy chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Trastoy, B, Cifuente, J.O, Du, J.J, Sundberg, E.J, Guerin, M.E.
登録日2022-06-16
公開日2023-04-05
最終更新日2023-07-26
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.
Nat Commun, 14, 2023
6EN3
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Crystal structure of full length EndoS from Streptococcus pyogenes in complex with G2 oligosaccharide.
分子名称: CALCIUM ION, Endo-beta-N-acetylglucosaminidase F2,Multifunctional-autoprocessing repeats-in-toxin, NICKEL (II) ION, ...
著者Trastoy, B, Klontz, E.H, Orwenyo, J, Marina, A, Wang, L.X, Sundberg, E.J, Guerin, M.E.
登録日2017-10-04
公開日2018-06-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.903 Å)
主引用文献Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S.
Nat Commun, 9, 2018
7NWF
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Crystal structure of Bacteroides thetaiotamicron EndoBT-3987 in complex with hybrid-type glycan (GalGlcNAcMan5GlcNAc) product
分子名称: Endo-beta-N-acetylglucosaminidase F1, GLYCEROL, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Trastoy, B, Du, J.J, Garcia-Alija, M, Sundberg, E.J, Guerin, M.E.
登録日2021-03-16
公開日2021-08-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献GH18 endo-beta-N-acetylglucosaminidases use distinct mechanisms to process hybrid-type N-linked glycans.
J.Biol.Chem., 297, 2021

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