8A64

cryoEM structure of the catalytically inactive EndoS from S. pyogenes in complex with the Fc region of immunoglobulin G1.

This is a non-PDB format compatible entry.

Summary for 8A64

• Entry DOI: 10.2210/pdb8a64/pdb
• EMDB information: 15205
• Descriptor: Endo-beta-N-acetylglucosaminidase F2, Immunoglobulin gamma-1 heavy chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: endoglycosidase s, endos, endo-b-n-acetylglucosaminidase, fc region, antibody, immunoglobulin g1, streptococcus pyogenes, n-glycans, hydrolase
• Biological source: Streptococcus pyogenes; More
• Total number of polymer chains: 3
• Total formula weight: 207656.86

Authors

Trastoy, B.,Cifuente, J.O.,Du, J.J.,Sundberg, E.J.,Guerin, M.E. (deposition date: 2022-06-16, release date: 2023-04-05, Last modification date: 2023-07-26)

• Primary citation: Trastoy, B.,Du, J.J.,Cifuente, J.O.,Rudolph, L.,Garcia-Alija, M.,Klontz, E.H.,Deredge, D.,Sultana, N.,Huynh, C.G.,Flowers, M.W.,Li, C.,Sastre, D.E.,Wang, L.X.,Corzana, F.,Mallagaray, A.,Sundberg, E.J.,Guerin, M.E.; Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.; Nat Commun, 14:1705-1705, 2023; PubMed: 36973249; DOI: 10.1038/s41467-023-37215-3

Experimental method

ELECTRON MICROSCOPY (4.6 Å)