8A64

cryoEM structure of the catalytically inactive EndoS from S. pyogenes in complex with the Fc region of immunoglobulin G1.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005576	cellular_component	extracellular region
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0033925	molecular_function	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
A	0042783	biological_process	symbiont-mediated evasion of host immune response
A	0043655	cellular_component	host extracellular space
A	0046872	molecular_function	metal ion binding
A	0090729	molecular_function	toxin activity
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0005576	cellular_component	extracellular region
B	0005886	cellular_component	plasma membrane
B	0016020	cellular_component	membrane
B	0019814	cellular_component	immunoglobulin complex
C	0002250	biological_process	adaptive immune response
C	0002376	biological_process	immune system process
C	0005576	cellular_component	extracellular region
C	0005886	cellular_component	plasma membrane
C	0016020	cellular_component	membrane
C	0019814	cellular_component	immunoglobulin complex

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
B	TYR198-HIS204
B	PHE423-HIS429

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:826475

Chain	Residue	Details
B	GLN-1
C	GLN-1

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN71
A	TYR402
C	ASN71
A	ARG186
A	ASP237
A	GLN303
A	TYR305
A	GLU349
A	GLU350
A	ASN356

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19358553

Chain	Residue	Details
B	ASN297
C	ASN297
A	GLN791
A	PRO915

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:24753590, ECO:0007744|PDB:4NUZ

Chain	Residue	Details
A	GLU916

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Cleavage; by S.pyogenes SpeB => ECO:0000269|PubMed:18182097

Chain	Residue	Details
A	LEU445

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