6C3U
Crystal structure of Klebsiella pneumoniae fosfomycin resistance protein (FosAKP) with inhibitor (ANY2) bound
Summary for 6C3U
Entry DOI | 10.2210/pdb6c3u/pdb |
Related | 5V3D 5V91 5WEW |
Descriptor | FosA family fosfomycin resistance glutathione transferase, MANGANESE (II) ION, 3-bromo-6-(4-nitro-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-2(1H)-one, ... (5 entities in total) |
Functional Keywords | fosfomycin, fosa, fosakp, glutathione s-transferase, any2, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 4 |
Total formula weight | 66849.55 |
Authors | Klontz, E.H.,Sundberg, E.J. (deposition date: 2018-01-10, release date: 2018-12-26, Last modification date: 2023-10-04) |
Primary citation | Tomich, A.D.,Klontz, E.H.,Deredge, D.,Barnard, J.P.,McElheny, C.L.,Eshbach, M.L.,Weisz, O.A.,Wintrode, P.,Doi, Y.,Sundberg, E.J.,Sluis-Cremer, N. Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens. Antimicrob. Agents Chemother., 63:-, 2019 Cited by PubMed: 30642934DOI: 10.1128/AAC.01524-18 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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