6C3U

Crystal structure of Klebsiella pneumoniae fosfomycin resistance protein (FosAKP) with inhibitor (ANY2) bound

Summary for 6C3U

Entry DOI	10.2210/pdb6c3u/pdb
Related	5V3D 5V91 5WEW
Descriptor	FosA family fosfomycin resistance glutathione transferase, MANGANESE (II) ION, 3-bromo-6-(4-nitro-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-2(1H)-one, ... (5 entities in total)
Functional Keywords	fosfomycin, fosa, fosakp, glutathione s-transferase, any2, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Klebsiella pneumoniae
Total number of polymer chains	4
Total formula weight	66849.55
Authors	Klontz, E.H.,Sundberg, E.J. (deposition date: 2018-01-10, release date: 2018-12-26, Last modification date: 2023-10-04)
Primary citation	Tomich, A.D.,Klontz, E.H.,Deredge, D.,Barnard, J.P.,McElheny, C.L.,Eshbach, M.L.,Weisz, O.A.,Wintrode, P.,Doi, Y.,Sundberg, E.J.,Sluis-Cremer, N. Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens. Antimicrob. Agents Chemother., 63:-, 2019 Cited by PubMed: 30642934 DOI: 10.1128/AAC.01524-18 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation