5WEP
Crystal structure of fosfomycin resistance protein FosA3 with inhibitor (ANY1) bound
Summary for 5WEP
Entry DOI | 10.2210/pdb5wep/pdb |
Related | 5VB0 |
Descriptor | FosA3, 6,6'-(4-nitro-1H-pyrazole-3,5-diyl)bis(3-bromopyrazolo[1,5-a]pyrimidin-2(1H)-one), ZINC ION (3 entities in total) |
Functional Keywords | fosfomycin, fosa, fosa3, glutathione s-transferase, any1, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 33697.39 |
Authors | Klontz, E.H.,Sundberg, E.J. (deposition date: 2017-07-10, release date: 2018-07-18, Last modification date: 2023-10-04) |
Primary citation | Tomich, A.D.,Klontz, E.H.,Deredge, D.,Barnard, J.P.,McElheny, C.L.,Eshbach, M.L.,Weisz, O.A.,Wintrode, P.,Doi, Y.,Sundberg, E.J.,Sluis-Cremer, N. Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens. Antimicrob. Agents Chemother., 63:-, 2019 Cited by PubMed: 30642934DOI: 10.1128/AAC.01524-18 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.502 Å) |
Structure validation
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