6W32
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![BU of 6w32 by Molmil](/molmil-images/mine/6w32) | Crystal structure of Sfh5 | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Phosphatidylinositol transfer protein SFH5 | 著者 | Gulten, G, Khan, D, Aggarwal, A, Krieger, I, Sacchettini, J.C, Bankaitis, V.A. | 登録日 | 2020-03-08 | 公開日 | 2020-11-25 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins. Elife, 9, 2020
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6G31
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![BU of 6g31 by Molmil](/molmil-images/mine/6g31) | Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y bound to zoledronate | 分子名称: | Geranylgeranyl pyrophosphate synthase, MAGNESIUM ION, ZOLEDRONIC ACID | 著者 | Lisnyansky, M, Kapelushnik, N, Ben-Bassat, A, Marom, M, Loewenstein, A, Khananshvili, D, Giladi, M, Haitin, Y. | 登録日 | 2018-03-24 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures. Mol. Pharmacol., 94, 2018
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6G32
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![BU of 6g32 by Molmil](/molmil-images/mine/6g32) | Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y | 分子名称: | GLYCEROL, Geranylgeranyl pyrophosphate synthase | 著者 | Lisnyansky, M, Kapelushnik, N, Ben-Bassat, A, Marom, M, Loewenstein, A, Khananshvili, D, Giladi, M, Haitin, Y. | 登録日 | 2018-03-24 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.281 Å) | 主引用文献 | Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures. Mol. Pharmacol., 94, 2018
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3US9
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![BU of 3us9 by Molmil](/molmil-images/mine/3us9) | Crystal Structure of the NCX1 Intracellular Tandem Calcium Binding Domains(CBD12) | 分子名称: | CALCIUM ION, Sodium/calcium exchanger 1 | 著者 | Giladi, M, Sasson, Y, Hirsch, J.A, Khananshvili, D. | 登録日 | 2011-11-23 | 公開日 | 2012-07-11 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | A common Ca2+-driven interdomain module governs eukaryotic NCX regulation. Plos One, 7, 2012
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2NC2
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![BU of 2nc2 by Molmil](/molmil-images/mine/2nc2) | |
6F0E
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![BU of 6f0e by Molmil](/molmil-images/mine/6f0e) | Structure of yeast Sec14p with a picolinamide compound | 分子名称: | SEC14 cytosolic factor, ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-bromanyl-3-fluoranyl-pyridine-2-carboxamide | 著者 | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | 登録日 | 2017-11-20 | 公開日 | 2018-01-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties. Cell Chem Biol, 25, 2018
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7ZGB
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![BU of 7zgb by Molmil](/molmil-images/mine/7zgb) | Structure of yeast Sec14p with NPPM112 | 分子名称: | 4-fluoranyl-~{N}-[(4-pyrrolidin-1-ylphenyl)methyl]benzamide, SEC14 cytosolic factor | 著者 | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | 登録日 | 2022-04-03 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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7ZGA
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![BU of 7zga by Molmil](/molmil-images/mine/7zga) | Structure of yeast Sec14p with ergoline | 分子名称: | SEC14 cytosolic factor, ~{O}9-methyl ~{O}4-[2,2,2-tris(chloranyl)ethyl] (5~{a}~{S},6~{a}~{S},9~{R},10~{a}~{S})-7-methyl-3-nitro-5,5~{a},6,6~{a},8,9,10,10~{a}-octahydroindolo[4,3-fg]quinoline-4,9-dicarboxylate | 著者 | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | 登録日 | 2022-04-03 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | 主引用文献 | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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7ZG9
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![BU of 7zg9 by Molmil](/molmil-images/mine/7zg9) | Structure of yeast Sec14p with himbacine | 分子名称: | Himbacine, SEC14 cytosolic factor | 著者 | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | 登録日 | 2022-04-03 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.764 Å) | 主引用文献 | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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7ZGC
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![BU of 7zgc by Molmil](/molmil-images/mine/7zgc) | Structure of yeast Sec14p with NPPM481 | 分子名称: | (4-chloranyl-3-nitro-phenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone, PHOSPHATE ION, SEC14 cytosolic factor | 著者 | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | 登録日 | 2022-04-03 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.236 Å) | 主引用文献 | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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7ZGD
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![BU of 7zgd by Molmil](/molmil-images/mine/7zgd) | Structure of yeast Sec14p with NPPM244 | 分子名称: | (4-bromanyl-3-nitro-phenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone, SEC14 cytosolic factor | 著者 | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | 登録日 | 2022-04-03 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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5CZB
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![BU of 5czb by Molmil](/molmil-images/mine/5czb) | HCV NS5B IN COMPLEX WITH LIGAND IDX17119-5 | 分子名称: | 1-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-3-{[(R)-(2,4-dimethylphenyl)(methoxy)phosphoryl]amino}-1H-pyrazole-4-carboxylic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Pierra, C, Dousson, C, Augustin, M. | 登録日 | 2015-07-31 | 公開日 | 2016-06-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase. Bioorg.Med.Chem.Lett., 26, 2016
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6N0J
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![BU of 6n0j by Molmil](/molmil-images/mine/6n0j) | The complex of CCG-222740 bound to pirin | 分子名称: | (3S)-N-(4-chlorophenyl)-5,5-difluoro-1-[3-(furan-2-yl)benzene-1-carbonyl]piperidine-3-carboxamide, 1,2-ETHANEDIOL, FE (III) ION, ... | 著者 | Lisabeth, E.M, Jin, X, Neubig, R. | 登録日 | 2018-11-07 | 公開日 | 2019-07-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds ACS Pharmacol Transl Sci, 2, 2019
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6N0K
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![BU of 6n0k by Molmil](/molmil-images/mine/6n0k) | The complex of CCG-257081 bound to pirin | 分子名称: | (3R)-N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyridin-4-yl)benzene-1-carbonyl]piperidine-3-carboxamide, 1,2-ETHANEDIOL, FE (III) ION, ... | 著者 | Lisabeth, E.M, Jin, X, Neubig, R. | 登録日 | 2018-11-07 | 公開日 | 2019-07-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds ACS Pharmacol Transl Sci, 2, 2019
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4LDC
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![BU of 4ldc by Molmil](/molmil-images/mine/4ldc) | Crystal Structure of DOC2B C2B domain | 分子名称: | CALCIUM ION, CITRATE ANION, Double C2-like domain-containing protein beta | 著者 | Giladi, M, Almagor, L, Hirsch, J.A. | 登録日 | 2013-06-24 | 公開日 | 2013-09-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.264 Å) | 主引用文献 | The C2B Domain Is the Primary Ca(2+) Sensor in DOC2B: A Structural and Functional Analysis. J.Mol.Biol., 425, 2013
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4LCV
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![BU of 4lcv by Molmil](/molmil-images/mine/4lcv) | Crystal Structure of DOC2B C2A domain | 分子名称: | BETA-MERCAPTOETHANOL, CALCIUM ION, CITRATE ANION, ... | 著者 | Giladi, M, Almagor, L, Hirsch, J.A. | 登録日 | 2013-06-23 | 公開日 | 2013-09-11 | 最終更新日 | 2013-11-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The C2B Domain Is the Primary Ca(2+) Sensor in DOC2B: A Structural and Functional Analysis. J.Mol.Biol., 425, 2013
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