2X9P
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![BU of 2x9p by Molmil](/molmil-images/mine/2x9p) | X-ray structure of the substrate-free cytochrome P450 PimD - a polyene macrolide antibiotic pimaricin epoxidase | 分子名称: | PIMD PROTEIN, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | 著者 | Kells, P.M, Ouellet, H, Santos-Aberturas, J, Aparicio, J.F, Podust, L.M. | 登録日 | 2010-03-23 | 公開日 | 2010-08-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of Cytochrome P450 Pimd Suggests Epoxidation of the Polyene Macrolide Pimaricin Occurs Via a Hydroperoxoferric Intermediate. Chem.Biol., 17, 2010
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2XBK
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![BU of 2xbk by Molmil](/molmil-images/mine/2xbk) | X-ray structure of the substrate-bound cytochrome P450 PimD - a polyene macrolide antibiotic pimaricin epoxidase | 分子名称: | 4,5-DE-EPOXYPIMARICIN, PIMD PROTEIN, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Kells, P.M, Ouellet, H, Santos-Aberturas, J, Aparicio, J.F, Podust, L.M. | 登録日 | 2010-04-12 | 公開日 | 2010-08-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure of Cytochrome P450 Pimd Suggests Epoxidation of the Polyene Macrolide Pimaricin Occurs Via a Hydroperoxoferric Intermediate. Chem.Biol., 17, 2010
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3ZBY
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![BU of 3zby by Molmil](/molmil-images/mine/3zby) | Ligand-free structure of CYP142 from Mycobacterium smegmatis | 分子名称: | 1,2-ETHANEDIOL, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), P450 HEME-THIOLATE PROTEIN, ... | 著者 | Garcia-Fernandez, E, Frank, D.J, Galan, B, Kells, P.M, Podust, L.M, Garcia, J.L, Ortiz de Montellano, P.R. | 登録日 | 2012-11-13 | 公開日 | 2013-02-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | A Highly Conserved Mycobacterial Cholesterol Catabolic Pathway. Environ.Microbiol., 15, 2013
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3ZSN
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![BU of 3zsn by Molmil](/molmil-images/mine/3zsn) | Structure of the mixed-function P450 MycG F286A mutant in complex with mycinamicin IV | 分子名称: | BENZAMIDINE, GLYCEROL, MYCINAMICIN IV, ... | 著者 | Li, S, Kells, P.M, Rutaganira, F.U, Anzai, Y, Kato, F, Sherman, D.H, Podust, L.M. | 登録日 | 2011-06-29 | 公開日 | 2012-05-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
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4APY
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![BU of 4apy by Molmil](/molmil-images/mine/4apy) | Ethylene glycol-bound form of P450 CYP125A3 from Mycobacterium smegmatis | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, P450 HEME-THIOLATE PROTEIN, ... | 著者 | Frank, D.J, Garcia Fernandez, E, Kells, P.M, Garcia Lopez, J.L, Podust, L.M, Ortiz de Montellano, P.R. | 登録日 | 2012-04-09 | 公開日 | 2013-02-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Highly Conserved Mycobacterial Cholesterol Catabolic Pathway. Environ.Microbiol., 15, 2013
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4AW3
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![BU of 4aw3 by Molmil](/molmil-images/mine/4aw3) | Structure of the mixed-function P450 MycG F286V mutant in complex with mycinamicin V in P1 space group | 分子名称: | GLYCEROL, MYCINAMICIN V, P-450-LIKE PROTEIN, ... | 著者 | Li, S, Tietz, D.R, Rutaganira, F.U, Kells, P.M, Anzai, Y, Kato, F, Pochapsky, T.C, Sherman, D.H, Podust, L.M. | 登録日 | 2012-05-30 | 公開日 | 2012-09-05 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
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2YGX
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![BU of 2ygx by Molmil](/molmil-images/mine/2ygx) | Structure of the mixed-function P450 MycG in P21 space group | 分子名称: | GLYCEROL, P-450-LIKE PROTEIN, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Li, S, Kells, P.M, Rutaganira, F.U, Sherman, D.H, Podust, L.M. | 登録日 | 2011-04-22 | 公開日 | 2012-02-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
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2X5L
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![BU of 2x5l by Molmil](/molmil-images/mine/2x5l) | X-RAY STRUCTURE OF THE SUBSTRATE-FREE MYCOBACTERIUM TUBERCULOSIS CYTOCHROME P450 CYP125, ALTERNATIVE CRYSTAL FORM | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 125 | 著者 | Ouellet, H, Kells, P.M, Ortiz de Montellano, P.R, Podust, L.M. | 登録日 | 2010-02-10 | 公開日 | 2010-11-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Reverse Type I Inhibitor of Mycobacteriumtuberculosis Cyp125A1. Bioorg.Med.Chem.Lett., 21, 2011
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2WM4
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![BU of 2wm4 by Molmil](/molmil-images/mine/2wm4) | X-ray structure of Mycobacterium tuberculosis cytochrome P450 CYP124 in complex with phytanic acid | 分子名称: | (3R,7S,11S)-3,7,11,15-tetramethylhexadecanoic acid, CALCIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Johnston, J.B, Kells, P.M, Podust, L.M, Ortiz de Montellano, P.R. | 登録日 | 2009-06-30 | 公開日 | 2009-10-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A., 106, 2009
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2X5W
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![BU of 2x5w by Molmil](/molmil-images/mine/2x5w) | X-ray structure of Mycobacterium tuberculosis cytochrome P450 CYP125 in complex with substrate cholest-4-en-3-one | 分子名称: | (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE, 1,2-ETHANEDIOL, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Ouellet, H, Guan, S, Johnston, J.B, Chow, E.D, Kells, P.M, Burlingame, A.L, Cox, J.S, Podust, L.M, Ortiz de Montellano, P.R. | 登録日 | 2010-02-10 | 公開日 | 2010-06-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Mycobacterium Tuberculosis Cyp125A1, a Steroid C27 Monooxygenase that Detoxifies Intracellularly Generated Cholest-4-En-3-One. Mol.Microbiol., 77, 2010
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2XN8
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![BU of 2xn8 by Molmil](/molmil-images/mine/2xn8) | X-RAY STRUCTURE OF THE SUBSTRATE-FREE MYCOBACTERIUM TUBERCULOSIS CYTOCHROME P450 CYP125 | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 125, SULFATE ION | 著者 | Ouellet, H, Kells, P.M, Ortiz de Montellano, P.R, Podust, L.M. | 登録日 | 2010-07-30 | 公開日 | 2010-11-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Reverse Type I Inhibitor of Mycobacteriumtuberculosis Cyp125A1. Bioorg.Med.Chem.Lett., 21, 2011
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2YCA
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![BU of 2yca by Molmil](/molmil-images/mine/2yca) | Mixed-function P450 MycG in complex with mycinamicin III in P21212 space group | 分子名称: | GLYCEROL, MYCINAMICIN III, P-450-LIKE PROTEIN, ... | 著者 | Li, S, Kells, P.M, Sherman, D.H, Podust, L.M. | 登録日 | 2011-03-12 | 公開日 | 2012-03-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
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2Y98
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![BU of 2y98 by Molmil](/molmil-images/mine/2y98) | Structure of the mixed-function P450 MycG in complex with mycinamicin IV in P21212 space group | 分子名称: | CHLORIDE ION, GLYCEROL, MYCINAMICIN IV, ... | 著者 | Li, S, Kells, P.M, Sherman, D.H, Podust, L.M. | 登録日 | 2011-02-12 | 公開日 | 2012-02-22 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
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2Y46
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![BU of 2y46 by Molmil](/molmil-images/mine/2y46) | Structure of the mixed-function P450 MycG in complex with mycinamicin IV in C 2 2 21 space group | 分子名称: | BENZAMIDINE, GLYCEROL, MYCINAMICIN IV, ... | 著者 | Li, S, Kells, P.M, Sherman, D.H, Podust, L.M. | 登録日 | 2011-01-05 | 公開日 | 2012-01-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
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2Y5N
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![BU of 2y5n by Molmil](/molmil-images/mine/2y5n) | Structure of the mixed-function P450 MycG in complex with mycinamicin V in P21 space group | 分子名称: | GLYCEROL, MAGNESIUM ION, MYCINAMICIN V, ... | 著者 | Li, S, Kells, P.M, Sherman, D.H, Podust, L.M. | 登録日 | 2011-01-15 | 公開日 | 2012-02-01 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
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2Y5Z
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![BU of 2y5z by Molmil](/molmil-images/mine/2y5z) | Mixed-function P450 MycG in complex with mycinamicin III in C2221 space group | 分子名称: | BENZAMIDINE, GLYCEROL, MYCINAMICIN III, ... | 著者 | Li, S, Kells, P.M, Sherman, D.H, Podust, L.M. | 登録日 | 2011-01-19 | 公開日 | 2012-02-01 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
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2WM5
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![BU of 2wm5 by Molmil](/molmil-images/mine/2wm5) | X-ray structure of the substrate-free Mycobacterium tuberculosis cytochrome P450 CYP124 | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 124 | 著者 | Johnston, J.B, Kells, P.M, Podust, L.M, Ortiz de Montellano, P.R. | 登録日 | 2009-06-30 | 公開日 | 2009-10-06 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A., 106, 2009
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2XC3
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![BU of 2xc3 by Molmil](/molmil-images/mine/2xc3) | X-ray structure of Mycobacterium tuberculosis cyp125 bound to the reverse type I inhibitor | 分子名称: | NALPHA-[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]-N-PYRIDIN-4-YL-D-TRYPTOPHANAMIDE, PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 125 | 著者 | Ouellet, H, Kells, P.M, Ortiz de Montellano, P.R, Podust, L.M. | 登録日 | 2010-04-16 | 公開日 | 2010-11-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Reverse Type I Inhibitor of Mycobacteriumtuberculosis Cyp125A1. Bioorg.Med.Chem.Lett., 21, 2011
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2YOO
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![BU of 2yoo by Molmil](/molmil-images/mine/2yoo) | Cholest-4-en-3-one bound structure of CYP142 from Mycobacterium smegmatis | 分子名称: | (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE, MAGNESIUM ION, P450 HEME-THIOLATE PROTEIN, ... | 著者 | Garcia-Fernandez, E, Frank, D.J, Galan, B, Kells, P.M, Podust, L.M, Garcia, J.L, Ortiz de Montellano, P.R. | 登録日 | 2012-10-25 | 公開日 | 2013-02-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | A Highly Conserved Mycobacterial Cholesterol Catabolic Pathway. Environ.Microbiol., 15, 2013
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3ZK5
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![BU of 3zk5 by Molmil](/molmil-images/mine/3zk5) | PikC D50N mutant bound to the 10-DML analog with the 3-(N,N-dimethylamino)ethanoate anchoring group | 分子名称: | (3R,4S,5S,7R,9E,11R,12R)-12-ethyl-3,5,7,11-tetramethyl-2,8-dioxooxacyclododec-9-en-4-yl N,N-dimethylglycinate, CYTOCHROME P450 HYDROXYLASE PIKC, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Podust, L.M. | 登録日 | 2013-01-21 | 公開日 | 2014-01-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Directing Group-Controlled Regioselectivity in an Enzymatic C-H Bond Oxygenation. J.Am.Chem.Soc., 136, 2014
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5UHU
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![BU of 5uhu by Molmil](/molmil-images/mine/5uhu) | |
4B7S
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![BU of 4b7s by Molmil](/molmil-images/mine/4b7s) | |
4CBQ
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![BU of 4cbq by Molmil](/molmil-images/mine/4cbq) | Crystal structure of the thioredoxin reductase from Entamoeba histolytica with auranofin Au(I) bound to Cys286 | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GOLD ION, ... | 著者 | Parsonage, D, Kells, P.M, Hirata, K, Debnath, A, Poole, L.B, McKerrow, J.H, Reed, S.L, Podust, L.M. | 登録日 | 2013-10-16 | 公開日 | 2014-11-05 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | X-Ray Structures of Thioredoxin and Thioredoxin Reductase from Entamoeba Histolytica and Prevailing Hypothesis of the Mechanism of Auranofin Action. J.Struct.Biol., 194, 2016
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4CCQ
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![BU of 4ccq by Molmil](/molmil-images/mine/4ccq) | Crystal structure of the thioredoxin reductase from Entamoeba histolytica with NADP | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Parsonage, D, Kells, P.M, Hirata, K, Debnath, A, Poole, L.B, McKerrow, J.H, Reed, S.L, Podust, L.M. | 登録日 | 2013-10-24 | 公開日 | 2014-11-05 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | X-Ray Structures of Thioredoxin and Thioredoxin Reductase from Entamoeba Histolytica and Prevailing Hypothesis of the Mechanism of Auranofin Action. J.Struct.Biol., 194, 2016
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4CW9
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![BU of 4cw9 by Molmil](/molmil-images/mine/4cw9) | Entamoeba histolytica thiredoxin C34S mutant | 分子名称: | THIOREDOXIN | 著者 | Parsonage, D, Kells, P.M, Vieira, D.F, Hirata, K, Debnath, A, Poole, L.B, McKerrow, J.H, Reed, S.L, Podust, L.M. | 登録日 | 2014-04-01 | 公開日 | 2015-05-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | X-Ray Structures of Thioredoxin and Thioredoxin Reductase from Entamoeba Histolytica and Prevailing Hypothesis of the Mechanism of Auranofin Action. J.Struct.Biol., 194, 2016
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