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4CCQ

Crystal structure of the thioredoxin reductase from Entamoeba histolytica with NADP

Summary for 4CCQ
Entry DOI10.2210/pdb4ccq/pdb
Related4CCR
DescriptorTHIOREDOXIN REDUCTASE, 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywordsoxidoreductase, amoebiasis, redox metabolism, oxidative stress, auranofin
Biological sourceENTAMOEBA HISTOLYTICA
Total number of polymer chains2
Total formula weight70862.35
Authors
Parsonage, D.,Kells, P.M.,Hirata, K.,Debnath, A.,Poole, L.B.,McKerrow, J.H.,Reed, S.L.,Podust, L.M. (deposition date: 2013-10-24, release date: 2014-11-05, Last modification date: 2023-12-20)
Primary citationParsonage, D.,Sheng, F.,Hirata, K.,Debnath, A.,Mckerrow, J.H.,Reed, S.L.,Abagyan, R.,Poole, L.B.,Podust, L.M.
X-Ray Structures of Thioredoxin and Thioredoxin Reductase from Entamoeba Histolytica and Prevailing Hypothesis of the Mechanism of Auranofin Action.
J.Struct.Biol., 194:180-, 2016
Cited by
PubMed: 26876147
DOI: 10.1016/J.JSB.2016.02.015
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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