Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019430 | biological_process | removal of superoxide radicals |
| A | 0045454 | biological_process | cell redox homeostasis |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019430 | biological_process | removal of superoxide radicals |
| B | 0045454 | biological_process | cell redox homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 1315 |
| Chain | Residue |
| A | ALA43 |
| A | GLY44 |
| A | THR48 |
| A | MET69 |
| A | MET70 |
| A | ARG73 |
| A | HOH2020 |
| A | HOH2108 |
| A | HOH2448 |
| site_id | AC2 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAP B 1315 |
| Chain | Residue |
| B | LYS122 |
| B | GLY160 |
| B | GLY161 |
| B | ASP162 |
| B | ALA163 |
| B | HIS182 |
| B | ARG183 |
| B | ARG184 |
| B | ARG188 |
| B | ALA245 |
| B | ILE246 |
| B | TYR290 |
| B | ARG291 |
| B | GLN292 |
| B | HOH2178 |
| B | HOH2227 |
| B | HOH2228 |
| B | HOH2229 |
| B | HOH2231 |
| B | HOH2232 |
| B | HOH2243 |
| B | HOH2246 |
| B | HOH2324 |
| B | HOH2383 |
| B | HOH2404 |
| B | HOH2405 |
| B | HOH2407 |
| B | HOH2409 |
| B | HOH2410 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAP A 1316 |
| Chain | Residue |
| A | GLY160 |
| A | GLY161 |
| A | ASP162 |
| A | ALA163 |
| A | GLU166 |
| A | HIS182 |
| A | ARG183 |
| A | ARG184 |
| A | ARG188 |
| A | ALA245 |
| A | ILE246 |
| A | HOH2230 |
| A | HOH2268 |
| A | HOH2269 |
| A | HOH2283 |
| A | HOH2295 |
| A | HOH2297 |
| A | HOH2360 |
| A | HOH2361 |
| A | HOH2364 |
| A | HOH2450 |
| A | HOH2451 |
| A | HOH2452 |
| A | HOH2453 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 1317 |
| Chain | Residue |
| A | GLU270 |
| A | THR274 |
| A | HOH2378 |
| A | HOH2407 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 1316 |
| Chain | Residue |
| B | ALA43 |
| B | GLY44 |
| B | THR48 |
| B | MET69 |
| B | MET70 |
| B | ARG73 |
| B | HOH2019 |
| B | HOH2103 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 1317 |
| Chain | Residue |
| A | HOH2242 |
| B | LEU268 |
| B | LYS273 |
| B | THR274 |
| B | SER275 |
| B | HOH2343 |
| site_id | AC7 |
| Number of Residues | 42 |
| Details | BINDING SITE FOR RESIDUE FAD A 1318 |
| Chain | Residue |
| A | THR87 |
| A | ILE88 |
| A | ALA116 |
| A | THR117 |
| A | GLY118 |
| A | ALA119 |
| A | HIS248 |
| A | GLY283 |
| A | ASP284 |
| A | ARG291 |
| A | GLN292 |
| A | ALA293 |
| A | ALA296 |
| A | HOH2016 |
| A | HOH2047 |
| A | HOH2073 |
| A | HOH2080 |
| A | HOH2083 |
| A | HOH2088 |
| A | HOH2224 |
| A | HOH2225 |
| A | HOH2454 |
| B | TYR22 |
| A | ILE10 |
| A | GLY11 |
| A | SER12 |
| A | GLY13 |
| A | PRO14 |
| A | ALA15 |
| A | TYR33 |
| A | GLU34 |
| A | GLY35 |
| A | ALA38 |
| A | VAL41 |
| A | ALA42 |
| A | ALA43 |
| A | GLY45 |
| A | GLN46 |
| A | LEU47 |
| A | THR49 |
| A | THR50 |
| A | ASN55 |
| site_id | AC8 |
| Number of Residues | 41 |
| Details | BINDING SITE FOR RESIDUE FAD B 1318 |
| Chain | Residue |
| A | TYR22 |
| A | HOH2027 |
| B | ILE10 |
| B | GLY11 |
| B | SER12 |
| B | GLY13 |
| B | PRO14 |
| B | ALA15 |
| B | TYR33 |
| B | GLU34 |
| B | GLY35 |
| B | ALA38 |
| B | VAL41 |
| B | ALA42 |
| B | GLY45 |
| B | GLN46 |
| B | LEU47 |
| B | THR50 |
| B | ILE53 |
| B | ASN55 |
| B | THR87 |
| B | ILE88 |
| B | ALA116 |
| B | THR117 |
| B | GLY118 |
| B | ALA119 |
| B | GLY283 |
| B | ASP284 |
| B | ARG291 |
| B | GLN292 |
| B | ALA293 |
| B | ALA296 |
| B | HOH2016 |
| B | HOH2039 |
| B | HOH2056 |
| B | HOH2064 |
| B | HOH2070 |
| B | HOH2071 |
| B | HOH2169 |
| B | HOH2171 |
| B | HOH2331 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 23 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CaiCDGavpiFrnkvLmVVGGGD |
| Chain | Residue | Details |
| A | CYS140-ASP162 | |
