8Z5L
 
 | | Crystal structure of metallo-beta-lactamse, IMP-1, complexed with a quinolinone-based inhibitor | | 分子名称: | 3-[2-azanyl-5-[2-cyclohexylethyl-[3-(4-methylphenoxy)propyl]amino]phenyl]propanoic acid, Metallo-beta-lactamase type 2, ZINC ION | | 著者 | Kamo, T, Kuroda, K, Nimura, S, Guo, Y, Kondo, S, Nukaga, M, Hoshino, T. | | 登録日 | 2024-04-18 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Development of Inhibitory Compounds for Metallo-beta-lactamase through Computational Design and Crystallographic Analysis.
Biochemistry, 63, 2024
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6JKB
 | | Crystal structure of metallo-beta-lactamse, NDM-1, in complex with hydrolyzed ampicillin | | 分子名称: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Metallo-beta-lactamase type 2, ZINC ION | | 著者 | Kamo, T, Kuroda, K, Kondo, S, Hayashi, U, Fudo, S, Nukaga, M, Hoshino, T. | | 登録日 | 2019-02-28 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.444 Å) | | 主引用文献 | Identification of the Inhibitory Compounds for Metallo-beta-lactamases and Structural Analysis of the Binding Modes.
Chem Pharm Bull (Tokyo), 69, 2021
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6JKA
 | | Crystal structure of metallo-beta-lactamse, IMP-1, in complex with a thiazole-bearing inhibitor | | 分子名称: | 3-[2-azanyl-5-[2-(phenoxymethyl)-1,3-thiazol-4-yl]phenyl]propanoic acid, 6-[2-(phenoxymethyl)-1,3-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one, Metallo-beta-lactamase type 2, ... | | 著者 | Kamo, T, Kuroda, K, Kondo, S, Hayashi, U, Fudo, S, Nukaga, M, Hoshino, T. | | 登録日 | 2019-02-28 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.006 Å) | | 主引用文献 | Identification of the Inhibitory Compounds for Metallo-beta-lactamases and Structural Analysis of the Binding Modes.
Chem Pharm Bull (Tokyo), 69, 2021
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7WEW
 | | Structure of adenylation domain of epsilon-poly-L-lysine synthase | | 分子名称: | ADENOSINE-5'-[LYSYL-PHOSPHATE], Epsilon-poly-L-lysine synthase, GLYCEROL, ... | | 著者 | Okamoto, T, Yamanaka, K, Hamano, Y, Nagano, S, Hino, T. | | 登録日 | 2021-12-24 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the adenylation domain from an epsilon-poly-l-lysine synthetase provides molecular mechanism for substrate specificity
Biochem.Biophys.Res.Commun., 596, 2022
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6K4I
 | | The partially disordered conformation of ubiquitin (Q41N variant) | | 分子名称: | ubiquitin | | 著者 | Wakamoto, T, Ikeya, T, Kitazawa, S, Baxter, N.J, Williamson, M.P, Kitahara, R. | | 登録日 | 2019-05-24 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Paramagnetic relaxation enhancement-assisted structural characterization of a partially disordered conformation of ubiquitin.
Protein Sci., 28, 2019
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1XWP
 | | Solution structure of AUCGCA loop | | 分子名称: | 5'-R(*GP*GP*AP*GP*AP*UP*CP*GP*CP*AP*CP*UP*CP*CP*A)-3' | | 著者 | Sakamoto, T, Oguro, A, Kawai, G, Ohtsu, T, Nakamura, Y. | | 登録日 | 2004-11-02 | | 公開日 | 2005-02-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structures of double loops of an RNA aptamer against mammalian initiation factor 4A
Nucleic Acids Res., 33, 2005
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1XWU
 | | Solution structure of ACAUAGA loop | | 分子名称: | 5'-R(*CP*GP*AP*AP*AP*CP*AP*UP*AP*GP*AP*UP*UP*CP*GP*A)-3' | | 著者 | Sakamoto, T, Oguro, A, Kawai, G, Ohtsu, T, Nakamura, Y. | | 登録日 | 2004-11-02 | | 公開日 | 2005-02-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structures of double loops of an RNA aptamer against mammalian initiation factor 4A
Nucleic Acids Res., 33, 2005
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1L1W
 | | NMR structure of a SRP19 binding domain in human SRP RNA | | 分子名称: | SRP19 binding domain of SRP RNA | | 著者 | Sakamoto, T, Morita, S, Tabata, K, Nakamura, K, Kawai, G. | | 登録日 | 2002-02-20 | | 公開日 | 2002-05-22 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a SRP19 binding domain in human SRP RNA.
J.Biochem.(Tokyo), 132, 2002
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5AZD
 | | Crystal structure of thermophilic rhodopsin. | | 分子名称: | Bacteriorhodopsin | | 著者 | Mizutani, K, Hashimoto, N, Tsukamoto, T, Yamashita, K, Yamamoto, M, Sudo, Y, Murata, T. | | 登録日 | 2015-09-30 | | 公開日 | 2016-04-27 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | X-ray crystallographic structure of thermophilic rhodopsin: implications for high thermal stability and optogenetic availability.
To Be Published
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8HAL
 | | Cryo-EM structure of the CBP catalytic core bound to the H4K12acK16ac nucleosome, class 1 | | 分子名称: | CREB-binding protein, DNA (180-mer), Histone H2A type 1-B/E, ... | | 著者 | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | | 登録日 | 2022-10-26 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nat Commun, 14, 2023
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8HAG
 | | Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 1 (3.2 angstrom resolution) | | 分子名称: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | | 登録日 | 2022-10-26 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nat Commun, 14, 2023
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8HAH
 | | Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 2 (3.9 angstrom resolution) | | 分子名称: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | | 登録日 | 2022-10-26 | | 公開日 | 2023-05-17 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nat Commun, 14, 2023
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8HAI
 | | Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 1 (4.7 angstrom resolution) | | 分子名称: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | | 登録日 | 2022-10-26 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nat Commun, 14, 2023
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8HAM
 | | Cryo-EM structure of the CBP catalytic core bound to the H4K12acK16ac nucleosome, class 2 | | 分子名称: | CREB-binding protein, DNA (180-mer), Histone H2A type 1-B/E, ... | | 著者 | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | | 登録日 | 2022-10-26 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nat Commun, 14, 2023
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8HAJ
 | | Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 2 (4.8 angstrom resolution) | | 分子名称: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | | 登録日 | 2022-10-26 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nat Commun, 14, 2023
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8HAN
 | | Cryo-EM structure of the CBP catalytic core bound to the H4K12acK16ac nucleosome, class 3 | | 分子名称: | CREB-binding protein, DNA (180-mer), Histone H2A type 1-B/E, ... | | 著者 | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | | 登録日 | 2022-10-26 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nat Commun, 14, 2023
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8HAK
 | | Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 4 (4.5 angstrom resolution) | | 分子名称: | DNA (180-mer), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Kikuchi, M, Morita, S, Wakamori, M, Shin, S, Uchikubo-Kamo, T, Shirouzu, M, Umehara, T. | | 登録日 | 2022-10-26 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nat Commun, 14, 2023
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1WZ7
 | | Crystal structure of enhancer of rudimentary homologue (ERH) | | 分子名称: | Enhancer of rudimentary homolog | | 著者 | Arai, R, Kukimoto-Niino, M, Uda-Tochio, H, Morita, S, Uchikubo-Kamo, T, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2005-02-26 | | 公開日 | 2005-05-03 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of an enhancer of rudimentary homolog (ERH) at 2.1 Angstroms resolution.
Protein Sci., 14, 2005
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7FCI
 | | human NTCP in complex with YN69083 Fab | | 分子名称: | Fab Heavy chain, Fab Light chain, Sodium/bile acid cotransporter | | 著者 | Park, J.H, Iwamoto, M, Yun, J.H, Uchikubo-Kamo, T, Son, D, Jin, Z, Yoshida, H, Ohki, M, Ishimoto, N, Mizutani, K, Oshima, M, Muramatsu, M, Wakita, T, Shirouzu, M, Liu, K, Uemura, T, Nomura, N, Iwata, S, Watashi, K, Tame, J.R.H, Nishizawa, T, Lee, W, Park, S.Y. | | 登録日 | 2021-07-14 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural insights into the HBV receptor and bile acid transporter NTCP.
Nature, 606, 2022
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7DPA
 | | Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex | | 分子名称: | Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 | | 著者 | Kukimoto-Niino, M, Katsura, K, Kaushik, R, Ehara, H, Yokoyama, T, Uchikubo-Kamo, T, Mishima-Tsumagari, C, Yonemochi, M, Ikeda, M, Hanada, K, Zhang, K.Y.J, Shirouzu, M. | | 登録日 | 2020-12-18 | | 公開日 | 2021-08-04 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex.
Sci Adv, 7, 2021
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8K9L
 | | Full agonist- and positive allosteric modulator-bound mu-type opioid receptor-G protein complex | | 分子名称: | (2~{S})-2-(3-bromanyl-4-methoxy-phenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine, DAMGO, G protein subunit alpha i3, ... | | 著者 | Hisano, T, Uchikubo-Kamo, T, Shirouzu, M, Imai, S, Kaneko, S, Shimada, I. | | 登録日 | 2023-08-01 | | 公開日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Structural and dynamic insights into the activation of the mu-opioid receptor by an allosteric modulator.
Nat Commun, 15, 2024
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8K9K
 | | Full agonist-bound mu-type opioid receptor-G protein complex | | 分子名称: | DAMGO, G protein subunit alpha i3, Guanine nucleotide binding protein, ... | | 著者 | Hisano, T, Uchikubo-Kamo, T, Shirouzu, M, Imai, S, Kaneko, S, Shimada, I. | | 登録日 | 2023-08-01 | | 公開日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Structural and dynamic insights into the activation of the mu-opioid receptor by an allosteric modulator.
Nat Commun, 15, 2024
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2YWK
 | | Crystal structure of RRM-domain derived from human putative RNA-binding protein 11 | | 分子名称: | Putative RNA-binding protein 11 | | 著者 | Kawazoe, M, Takemoto, C, Kaminishi, T, Uchikubo-Kamo, T, Nishino, A, Morita, S, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-04-20 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Crystal structure of RRM-domain derived from human putative RNA-binding protein 11
To be Published
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2Z16
 | | Crystal structure of Matrix protein 1 from influenza A virus A/crow/Kyoto/T1/2004(H5N1) | | 分子名称: | Matrix protein 1 | | 著者 | Saijo, S, Kishishita, S, Uchikubo-Kamo, T, Terada, T, Shirouzu, M, Ito, H, Ito, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-05-08 | | 公開日 | 2008-05-13 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Crystal structure of Matrix protein 1 from influenza A virus A/crow/Kyoto/T1/2004(H5N1)
To be Published
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3A3U
 | | Crystal structure of MqnD (TTHA1568), a menaquinone biosynthetic enzyme from Thermus thermophilus HB8 | | 分子名称: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, L(+)-TARTARIC ACID, Menaquinone biosynthetic enzyme, ... | | 著者 | Arai, R, Nishino, A, Nagano, K, Uchikubo-Kamo, T, Katsura, K, Nishimoto, M, Toyama, M, Terada, T, Kuramitsu, S, Murayama, K, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2009-06-20 | | 公開日 | 2009-07-14 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Crystal structure of MqnD (TTHA1568), a menaquinone biosynthetic enzyme from Thermus thermophilus HB8.
J.Struct.Biol., 168, 2009
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