6JKB

Crystal structure of metallo-beta-lactamse, NDM-1, in complex with hydrolyzed ampicillin

Summary for 6JKB

Entry DOI	10.2210/pdb6jkb/pdb
Descriptor	Metallo-beta-lactamase type 2, ZINC ION, (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ... (4 entities in total)
Functional Keywords	hydrolase, antibiotic
Biological source	Klebsiella pneumoniae
Total number of polymer chains	2
Total formula weight	52568.45
Authors	Kamo, T.,Kuroda, K.,Kondo, S.,Hayashi, U.,Fudo, S.,Nukaga, M.,Hoshino, T. (deposition date: 2019-02-28, release date: 2020-03-25, Last modification date: 2023-11-22)
Primary citation	Kamo, T.,Kuroda, K.,Kondo, S.,Hayashi, U.,Fudo, S.,Yoneda, T.,Takaya, A.,Nukaga, M.,Hoshino, T. Identification of the Inhibitory Compounds for Metallo-beta-lactamases and Structural Analysis of the Binding Modes. Chem Pharm Bull (Tokyo), 69:1179-1183, 2021 Cited by PubMed: 34853284 DOI: 10.1248/cpb.c21-00611 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.444 Å)

Structure validation