Search by PDB author - 日本蛋白質構造データバンク

English 日本語简体中文繁體中文 한국어

✖

ﾒﾆｭｰ

RCSB PDB PDBe BMRB Adv. Search Search help

Search by PDB author

Visualize

BU of 1yqj by Molmil

Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor
分子名称:	6((S)-3-BENZYLPIPERAZIN-1-YL)-3-(NAPHTHALEN-2-YL)-4-(PYRIDIN-4-YL)PYRAZINE, Mitogen-activated protein kinase 14, SULFATE ION
著者	Tamayo, N, Liao, H, Goldberg, M, Syed, R, Li, V, Powers, D, Tudor, Y, Yu, V, Wong, M.L, Henkle, B, Middelton, S, Harvey, T, Jang, G, Hungate, R, Dominguez, C.
登録日	2005-02-01
公開日	2005-04-26
最終更新日	2023-08-23
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase. Bioorg.Med.Chem.Lett., 15, 2005

Visualize

BU of 3jzk by Molmil

crystal structure of MDM2 with chromenotriazolopyrimidine 1
分子名称:	(6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine, E3 ubiquitin-protein ligase Mdm2
著者	Huang, X.
登録日	2009-09-23
公開日	2009-11-17
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J.Med.Chem., 52, 2009

Visualize

BU of 4phw by Molmil

Crystal Structure of PDE10A with 1H-benzimidazol-2-yl(4-((3-(tetrahydro-2H-pyran-4-yl)-2-pyridinyl)oxy)phenyl)methanone
分子名称:	1H-benzimidazol-2-yl(4-{[3-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl]oxy}phenyl)methanone, SULFATE ION, ZINC ION, ...
著者	Chmait, S.
登録日	2014-05-07
公開日	2014-08-06
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Discovery of Clinical Candidate 1-(4-(3-(4-(1H-Benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A). J.Med.Chem., 57, 2014

Visualize

BU of 4wwp by Molmil

Crystal structure of human PI3K-gamma in complex with pyridinylquinoline inhibitor N-{(1S)-1-[8-chloro-2-(2-methylpyridin-3-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine
分子名称:	GLYCEROL, N-{(1S)-1-[8-chloro-2-(2-methylpyridin-3-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, ...
著者	Whittington, D.A, Tang, J, Yakowec, P.
登録日	2014-11-11
公開日	2014-12-17
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K delta Inhibitors for Inflammation and Autoimmune Disease. J.Med.Chem., 58, 2015

Visualize

BU of 4wwn by Molmil

Crystal structure of human PI3K-gamma in complex with (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine AMG319 inhibitor
分子名称:	N-{(1S)-1-[7-fluoro-2-(pyridin-2-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
著者	Whittington, D.A, Tang, J, Yakowec, P.
登録日	2014-11-11
公開日	2014-12-17
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K delta Inhibitors for Inflammation and Autoimmune Disease. J.Med.Chem., 58, 2015

Visualize

BU of 4wwo by Molmil

Crystal structure of human PI3K-gamma in complex with phenylquinoline inhibitor N-{(1S)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}-9H-purin-6-amine
分子名称:	N-{(1S)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}-9H-purin-6-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
著者	Whittington, D.A, Tang, J, Yakowec, P.
登録日	2014-11-11
公開日	2014-12-17
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K delta Inhibitors for Inflammation and Autoimmune Disease. J.Med.Chem., 58, 2015

Visualize

BU of 3pdj by Molmil

Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with 4,4-Disubstituted Cyclohexylbenzamide Inhibitor
分子名称:	Corticosteroid 11-beta-dehydrogenase isozyme 1, N-[trans-4-(3-amino-3-oxopropyl)-4-phenylcyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者	Wang, Z, Sudom, A, Walker, N.P.
登録日	2010-10-22
公開日	2011-10-05
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Synthesis and Optimization of Novel 4,4-Disubstituted Cyclohexylbenzamide Derivatives as Potent 11beta-HSD1 Inhibitors Bioorg.Med.Chem.Lett., 21, 2011

Visualize

BU of 3l9m by Molmil

Crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 18
分子名称:	(2S)-N~1~-[5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)propane-1,2-diamine, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha
著者	Huang, X.
登録日	2010-01-05
公開日	2011-01-19
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Azole-based inhibitors of AKT/PKB for the treatment of cancer. Bioorg.Med.Chem.Lett., 20, 2010

Visualize

BU of 3l9n by Molmil

crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 27
分子名称:	(2S)-N~1~-[5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)propane-1,2-diamine, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha
著者	Huang, X.
登録日	2010-01-05
公開日	2011-01-19
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Azole-based inhibitors of AKT/PKB for the treatment of cancer. Bioorg.Med.Chem.Lett., 20, 2010

Visualize

BU of 3l9l by Molmil

Crystal structure of pka with compound 36
分子名称:	5-[2-({(2S)-2-amino-3-[4-(trifluoromethyl)phenyl]propyl}amino)-1,3-thiazol-5-yl]-1,3-dihydro-2H-indol-2-one, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha
著者	Huang, X.
登録日	2010-01-05
公開日	2011-01-19
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Azole-based inhibitors of AKT/PKB for the treatment of cancer. Bioorg.Med.Chem.Lett., 20, 2010

Visualize

BU of 3cpb by Molmil

Crystal structure of the VEGFR2 kinase domain in complex with a bisamide inhibitor
分子名称:	N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide, Vascular endothelial growth factor receptor 2
著者	Whittington, D.A, Long, A.M, Rose, P, Gu, Y, Zhao, H.
登録日	2008-03-31
公開日	2008-06-17
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit. J.Med.Chem., 51, 2008

Visualize

BU of 3dtw by Molmil

Crystal structure of the VEGFR2 kinase domain in complex with a benzisoxazole inhibitor
分子名称:	6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide, Vascular endothelial growth factor receptor 2
著者	Whittington, D.A, Long, A.M, Rose, P, Gu, Y, Zhao, H.
登録日	2008-07-16
公開日	2008-09-09
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	Discovery of amido-benzisoxazoles as potent c-Kit inhibitors. Bioorg.Med.Chem.Lett., 18, 2008

Visualize

BU of 3cpc by Molmil

Crystal structure of the VEGFR2 kinase domain in complex with a pyridone inhibitor
分子名称:	3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one, Vascular endothelial growth factor receptor 2
著者	Whittington, D.A, Long, A.M, Rose, P, Gu, Y, Zhao, H.
登録日	2008-03-31
公開日	2008-06-17
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit. J.Med.Chem., 51, 2008

Visualize

BU of 3cp9 by Molmil

Crystal structure of the VEGFR2 kinase domain in complex with a pyridone inhibitor
分子名称:	3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one, Vascular endothelial growth factor receptor 2
著者	Whittington, D.A, Long, A.M, Rose, P, Gu, Y, Zhao, H.
登録日	2008-03-31
公開日	2008-06-17
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit. J.Med.Chem., 51, 2008

Visualize

BU of 3fco by Molmil

Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Benzamide Inhibitor
分子名称:	Corticosteroid 11-beta-dehydrogenase isozyme 1, N-cyclopropyl-N-(cis-4-cyclopropyl-4-hydroxycyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者	Wang, Z, Sudom, A, Walker, N.P.
登録日	2008-11-21
公開日	2009-12-01
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.65 Å)
主引用文献	Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors. Bioorg.Med.Chem.Lett., 19, 2009

Visualize

BU of 3efk by Molmil

Structure of c-Met with pyrimidone inhibitor 50
分子名称:	5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methylpyrimidin-4(3H)-one, Hepatocyte growth factor receptor
著者	Bellon, S.F, D'Angelo, N, Whittington, D, Dussault, I.
登録日	2008-09-09
公開日	2008-10-07
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Design, synthesis, and biological evaluation of potent c-Met inhibitors. J.Med.Chem., 51, 2008

Visualize

BU of 3efj by Molmil

Structure of c-Met with pyrimidone inhibitor 7
分子名称:	2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methylpyrimidin-4(3H)-one, Hepatocyte growth factor receptor
著者	D'Angelo, N, Bellon, S, Whittington, D.
登録日	2008-09-09
公開日	2008-10-07
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Design, synthesis, and biological evaluation of potent c-Met inhibitors. J.Med.Chem., 51, 2008

222415

件を2024-07-10に公開中

PDB statistics

PDBj update info

Contact PDBj

numon