6NAQ
| Crystal structure of Neisseria meningitidis ClpP protease in Apo form | 分子名称: | ATP-dependent Clp protease proteolytic subunit, POTASSIUM ION | 著者 | Houry, W.A, Mabanglo, M.F, Pai, E.F, Eger, B.T, Bryson, S. | 登録日 | 2018-12-06 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.022 Å) | 主引用文献 | ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores. Commun Biol, 2, 2019
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5FL2
| Revisited cryo-EM structure of Inducible lysine decarboxylase complexed with LARA domain of RavA ATPase | 分子名称: | ATPASE RAVA, LYSINE DECARBOXYLASE, INDUCIBLE | 著者 | Kandiah, E, Carriel, D, Perard, J, Malet, H, Bacia, M, Liu, K, Chan, S.W.S, Houry, W.A, Ollagnier de Choudens, S, Elsen, S, Gutsche, I. | 登録日 | 2015-10-21 | 公開日 | 2016-09-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | 主引用文献 | Structural Insights Into the Escherichia Coli Lysine Decarboxylases and Molecular Determinants of Interaction with the Aaa+ ATPase Rava. Sci.Rep., 6, 2016
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5DKP
| Crystal Structure of N. meningitidis ClpP in complex with agonist ADEP A54556. | 分子名称: | ATP-dependent Clp protease proteolytic subunit, POTASSIUM ION, SODIUM ION, ... | 著者 | Goodreid, J.D, Janetzko, J, Santa Maria Jr, J.P, Wong, K, Leung, E, Eger, B.T, Bryson, S, Pai, E.F, Gray-Owen, S.D, Walker, S, Houry, W.A, Batey, R.A. | 登録日 | 2015-09-03 | 公開日 | 2016-01-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.381 Å) | 主引用文献 | Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity. J.Med.Chem., 59, 2016
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3N75
| X-ray Crystal Structure of the Escherichia coli Inducible Lysine Decarboxylase LdcI | 分子名称: | GLYCEROL, GUANOSINE-5',3'-TETRAPHOSPHATE, HEXAETHYLENE GLYCOL, ... | 著者 | Kanjee, U, Alexopoulos, E, Pai, E.F, Houry, W.A. | 登録日 | 2010-05-26 | 公開日 | 2011-02-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase. Embo J., 30, 2011
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1Y7O
| The structure of Streptococcus pneumoniae A153P ClpP | 分子名称: | ATP-dependent Clp protease proteolytic subunit, CALCIUM ION | 著者 | Kimber, M.S, Gribun, A, Ching, R, Sprangers, R, Fiebig, K.M, Houry, W.A. | 登録日 | 2004-12-09 | 公開日 | 2005-02-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formation. J.Biol.Chem., 280, 2005
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7UVR
| Crystal structure of human ClpP protease in complex with TR-65 | 分子名称: | 3-{[(10R)-4-[(4-chlorophenyl)methyl]-5-oxo-1,2,4,5,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-7(6H)-yl]methyl}benzonitrile, ATP-dependent Clp protease proteolytic subunit, mitochondrial | 著者 | Mabanglo, M.F, Houry, W.A. | 登録日 | 2022-05-02 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome. Structure, 31, 2023
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7UVU
| Crystal structure of human ClpP protease in complex with TR-107 | 分子名称: | 3-({3-[(4-chlorophenyl)methyl]-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl}methyl)benzonitrile, ATP-dependent Clp protease proteolytic subunit, mitochondrial | 著者 | Mabanglo, M.F, Houry, W.A. | 登録日 | 2022-05-02 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | 主引用文献 | Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome. Structure, 31, 2023
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7UW0
| Crystal structure of human ClpP protease in complex with TR-133 | 分子名称: | 3-({3-[(4-bromophenyl)methyl]-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl}methyl)benzonitrile, ATP-dependent Clp protease proteolytic subunit, mitochondrial | 著者 | Mabanglo, M.F, Houry, W.A. | 登録日 | 2022-05-02 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome. Structure, 31, 2023
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7UVM
| Crystal structure of human ClpP protease in complex with TR-27 | 分子名称: | (10R)-4-[(4-chlorophenyl)methyl]-7-[(3-ethynylphenyl)methyl]-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, ATP-dependent Clp protease proteolytic subunit, mitochondrial | 著者 | Mabanglo, M.F, Houry, W.A. | 登録日 | 2022-05-02 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome. Structure, 31, 2023
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7UVN
| Crystal structure of human ClpP protease in complex with TR-57 | 分子名称: | 3-({3-[(4-chlorophenyl)methyl]-1-methyl-2,4-dioxo-1,3,4,5,7,8-hexahydropyrido[4,3-d]pyrimidin-6(2H)-yl}methyl)benzonitrile, ATP-dependent Clp protease proteolytic subunit, mitochondrial | 著者 | Mabanglo, M.F, Houry, W.A. | 登録日 | 2022-05-02 | 公開日 | 2023-01-11 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome. Structure, 31, 2023
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2L6J
| Tah1 complexed by MEEVD | 分子名称: | C-terminus Hsp90 chaperone peptide MEEVD, TPR repeat-containing protein associated with Hsp90 | 著者 | Jimenez, B, Ugwu, F, Zhao, R, Orti, L, Houry, W.A, Pineda-Lucena, A. | 登録日 | 2010-11-22 | 公開日 | 2011-12-28 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of minimal tetratricopeptide repeat domain protein Tah1 reveals mechanism of its interaction with Pih1 and Hsp90. J.Biol.Chem., 287, 2012
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3HLN
| Crystal structure of ClpP A153C mutant with inter-heptamer disulfide bonds | 分子名称: | ATP-dependent Clp protease proteolytic subunit, CALCIUM ION | 著者 | Kimber, M.S, Yu, A.Y.H, Borg, M, Chan, H.S, Houry, W.A. | 登録日 | 2009-05-27 | 公開日 | 2010-07-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural and Theoretical Studies Indicate that the Cylindrical Protease ClpP Samples Extended and Compact Conformations. Structure, 18, 2010
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4UPB
| Electron cryo-microscopy of the complex formed between the hexameric ATPase RavA and the decameric inducible decarboxylase LdcI | 分子名称: | ATPASE RAVA, LYSINE DECARBOXYLASE, INDUCIBLE | 著者 | Malet, H, Liu, K, El Bakkouri, M, Chan, S.W.S, Effantin, G, Bacia, M, Houry, W.A, Gutsche, I. | 登録日 | 2014-06-15 | 公開日 | 2014-08-20 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (11 Å) | 主引用文献 | Assembly Principles of a Unique Cage Formed by Hexameric and Decameric E. Coli Proteins. Elife, 3, 2014
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4UPF
| Assembly principles of the unique cage formed by the ATPase RavA hexamer and the lysine decarboxylase LdcI decamer | 分子名称: | ATPASE RAVA, LYSINE DECARBOXYLASE, INDUCIBLE | 著者 | Malet, H, Liu, K, El Bakkouri, M, Chan, S.W.S, Effantin, G, Bacia, M, Houry, W.A, Gutsche, I. | 登録日 | 2014-06-16 | 公開日 | 2014-08-20 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (7.5 Å) | 主引用文献 | Assembly Principles of a Unique Cage Formed by Hexameric and Decameric E. Coli Proteins. Elife, 3, 2014
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3Q16
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7UGC
| Structure of the N-terminal domain of ViaA | 分子名称: | Protein ViaA | 著者 | Lemak, A, Reichheld, S, Bhandari, V, Houliston, S, Arrowsmith, C.H, Sharpe, S, Houry, W.A. | 登録日 | 2022-03-24 | 公開日 | 2023-03-29 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the N-terminal domain of ViaA To Be Published
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5FKZ
| Structure of E.coli Constitutive lysine decarboxylase | 分子名称: | LYSINE DECARBOXYLASE, CONSTITUTIVE | 著者 | Kandiah, E, Carriel, D, Perard, J, Malet, H, Bacia, M, Liu, K, Chan, S.W.S, Houry, W.A, Ollagnier de Choudens, S, Elsen, S, Gutsche, I. | 登録日 | 2015-10-20 | 公開日 | 2016-09-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | 主引用文献 | Structural Insights Into the Escherichia Coli Lysine Decarboxylases and Molecular Determinants of Interaction with the Aaa+ ATPase Rava. Sci.Rep., 6, 2016
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5FKX
| Structure of E.coli inducible lysine decarboxylase at active pH | 分子名称: | LYSINE DECARBOXYLASE, INDUCIBLE | 著者 | Kandiah, E, Carriel, D, Perard, J, Malet, H, Bacia, M, Liu, K, Chan, S.W.S, Houry, W.A, Ollagnier de Choudens, S, Elsen, S, Gutsche, I. | 登録日 | 2015-10-20 | 公開日 | 2016-09-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Structural Insights Into the Escherichia Coli Lysine Decarboxylases and Molecular Determinants of Interaction with the Aaa+ ATPase Rava. Sci.Rep., 6, 2016
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6VFX
| ClpXP from Neisseria meningitidis - Conformation B | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... | 著者 | Ripstein, Z.A, Vahidi, S, Houry, W.A, Rubinstein, J.L, Kay, L.E. | 登録日 | 2020-01-06 | 公開日 | 2020-01-22 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery. Elife, 9, 2020
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6VFS
| ClpXP from Neisseria meningitidis - Conformation A | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... | 著者 | Ripstein, Z.A, Vahidi, S, Houry, W.A, Rubinstein, J.L, Kay, L.E. | 登録日 | 2020-01-06 | 公開日 | 2020-01-22 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery. Elife, 9, 2020
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6W9T
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6NB1
| Crystal structure of Escherichia coli ClpP protease complexed with small molecule activator, ACP1-06 | 分子名称: | ATP-dependent Clp protease proteolytic subunit, GLYCEROL, N-{2-[(2-chlorophenyl)sulfanyl]ethyl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide | 著者 | Mabanglo, M.F, Houry, W.A, Eger, B.T, Bryson, S, Pai, E.F. | 登録日 | 2018-12-06 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores. Commun Biol, 2, 2019
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6NAH
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6NAW
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6NAY
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