4XQ7
 
 | | The crystal structure of the OAS-like domain (OLD) of human OASL | | 分子名称: | 2'-5'-oligoadenylate synthase-like protein | | 著者 | Ibsen, M.S, Gad, H.H, Andersen, L.L, Hornung, V, Julkunen, I, Sarkar, S.N, Hartmann, R. | | 登録日 | 2015-01-19 | | 公開日 | 2015-04-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling.
Nucleic Acids Res., 43, 2015
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7A08
 | | CryoEM Structure of cGAS Nucleosome complex | | 分子名称: | Cyclic GMP-AMP synthase, Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, ... | | 著者 | Michalski, S, de Oliveira Mann, C.C, Witte, G, Bartho, J, Lammens, K, Hopfner, K.P. | | 登録日 | 2020-08-07 | | 公開日 | 2020-09-23 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Structural basis for sequestration and autoinhibition of cGAS by chromatin.
Nature, 587, 2020
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6H1D
 | | Crystal structure of C21orf127-TRMT112 in complex with SAH | | 分子名称: | HemK methyltransferase family member 2, Multifunctional methyltransferase subunit TRM112-like protein, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Wang, S, Hermann, B, Metzger, E, Peng, L, Einsle, O, Schuele, R. | | 登録日 | 2018-07-11 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.
Nat.Struct.Mol.Biol., 26, 2019
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8S86
 | | human PLD3 homodimer structure | | 分子名称: | 5'-3' exonuclease PLD3 | | 著者 | Lammens, K. | | 登録日 | 2024-03-05 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation.
Immunity, 57, 2024
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5N6I
 | | Crystal structure of mouse cGAS in complex with 39 bp DNA | | 分子名称: | Cyclic GMP-AMP synthase, DNA (36-MER), DNA (37-MER), ... | | 著者 | Andreeva, L, Kostrewa, D, Hopfner, K.-P. | | 登録日 | 2017-02-15 | | 公開日 | 2017-09-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Nature, 549, 2017
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6H1E
 | | Crystal structure of C21orf127-TRMT112 in complex with SAH and H4 peptide | | 分子名称: | HemK methyltransferase family member 2, Histone H4 peptide, Multifunctional methyltransferase subunit TRM112-like protein, ... | | 著者 | Wang, S, Hermann, B, Metzger, E, Peng, L, Einsle, O, Schuele, R. | | 登録日 | 2018-07-11 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.
Nat.Struct.Mol.Biol., 26, 2019
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3RN5
 | | Structural basis of cytosolic DNA recognition by innate immune receptors | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*CP*AP*TP*CP*AP*AP*AP*GP*AP*GP*AP*GP*AP*AP*AP*GP*AP*G)-3'), DNA (5'-D(*GP*CP*TP*CP*TP*TP*TP*CP*TP*CP*TP*CP*TP*TP*TP*GP*AP*TP*G)-3'), ... | | 著者 | Jin, T.C, Xiao, T. | | 登録日 | 2011-04-21 | | 公開日 | 2012-04-25 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
Immunity, 36, 2012
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3RNU
 | | Structural Basis of Cytosolic DNA Sensing by Innate Immune Receptors | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*CP*AP*TP*CP*AP*AP*AP*GP*AP*GP*AP*GP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*CP*TP*CP*TP*TP*TP*GP*AP*TP*GP*GP*CP*C)-3'), ... | | 著者 | Jin, T.C, Xiao, T. | | 登録日 | 2011-04-22 | | 公開日 | 2012-04-25 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.502 Å) | | 主引用文献 | Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
Immunity, 36, 2012
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4L5T
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4L5R
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4L5Q
 | | Crystal structure of p202 HIN1 | | 分子名称: | Interferon-activable protein 202 | | 著者 | Yin, Q, Tian, Y, Wu, H. | | 登録日 | 2013-06-11 | | 公開日 | 2013-07-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Cell Rep, 4, 2013
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3RLN
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3RLO
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4L5S
 | | p202 HIN1 in complex with 12-mer dsDNA | | 分子名称: | 12-mer DNA, Interferon-activable protein 202, SULFATE ION | | 著者 | Yin, Q, Tian, Y, Wu, H. | | 登録日 | 2013-06-11 | | 公開日 | 2013-08-14 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | | 主引用文献 | Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Cell Rep, 4, 2013
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3RN2
 | | Structural Basis of Cytosolic DNA Recognition by Innate Immune Receptors | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*CP*AP*TP*CP*AP*AP*AP*GP*AP*TP*CP*TP*TP*TP*GP*AP*TP*GP*G)-3'), Interferon-inducible protein AIM2 | | 著者 | Jin, T.C, Xiao, T. | | 登録日 | 2011-04-21 | | 公開日 | 2012-04-25 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
Immunity, 36, 2012
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6G9P
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4JC5
 | | Immune activator bound to receptor | | 分子名称: | (9-oxoacridin-10(9H)-yl)acetic acid, Transmembrane protein 173 | | 著者 | Deimling, T, Hopfner, K.P. | | 登録日 | 2013-02-21 | | 公開日 | 2013-05-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Species-specific detection of the antiviral small-molecule compound CMA by STING.
Embo J., 32, 2013
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4JLZ
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4KB6
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4JLX
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