6H1E

Crystal structure of C21orf127-TRMT112 in complex with SAH and H4 peptide

Summary for 6H1E

Entry DOI	10.2210/pdb6h1e/pdb
Descriptor	HemK methyltransferase family member 2, Multifunctional methyltransferase subunit TRM112-like protein, Histone H4 peptide, ... (5 entities in total)
Functional Keywords	protein methyltransferase, histone methylation, complex, sah, gene regulation
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	39114.99
Authors	Wang, S.,Hermann, B.,Metzger, E.,Peng, L.,Einsle, O.,Schuele, R. (deposition date: 2018-07-11, release date: 2019-05-22, Last modification date: 2024-01-17)
Primary citation	Metzger, E.,Wang, S.,Urban, S.,Willmann, D.,Schmidt, A.,Offermann, A.,Allen, A.,Sum, M.,Obier, N.,Cottard, F.,Ulferts, S.,Preca, B.T.,Hermann, B.,Maurer, J.,Greschik, H.,Hornung, V.,Einsle, O.,Perner, S.,Imhof, A.,Jung, M.,Schule, R. KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. Nat.Struct.Mol.Biol., 26:361-371, 2019 Cited by PubMed: 31061526 DOI: 10.1038/s41594-019-0219-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation