6H1E

Crystal structure of C21orf127-TRMT112 in complex with SAH and H4 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HemK methyltransferase family member 2	polymer	208	22344.7	1	UniProt (Q9Y5N5) Pfam (PF05175)	Homo sapiens (Human)	M.HsaHemK2P,N(6)-adenine-specific DNA methyltransferase 1
2	B (B)	Multifunctional methyltransferase subunit TRM112-like protein	polymer	126	14272.4	1	UniProt (Q9UI30) Pfam (PF03966)	Homo sapiens (Human)	tRNA methyltransferase 112 homolog
3	C (S)	Histone H4 peptide	polymer	21	2113.5	1		Homo sapiens
4	D (A)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (177678424) PubChem (46936206) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (6419189) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (164157219) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
5	E, F (A, B)	water	water		18.0	74	Chemie (HOH)

Sequence modifications

A: 8 - 214 (UniProt: Q9Y5N5)

PDB	External Database	Details
Ser 7	-	expression tag

B: 3 - 126 (UniProt: Q9UI30)

PDB	External Database	Details
Met 1	-	initiating methionine
Gly 2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	38730.6
Non-Polymers*	Number of molecules	1
	Total formula weight	384.4
All*	Total formula weight	39115.0

*Water molecules are not included.